中国感染控制杂志2017，Vol.16Issue(2)：130-133,137,5.DOI:10.3969/j.issn.1671-9638.2017.02.007
某院耐碳青霉烯类肺炎克雷伯菌检出与耐药表型分布
Isolation and drug resistance phenotype distribution of carbapenem-resistant Klebsiella pneumoniae in a hospital
摘要
Abstract
Objective To analyze drug resistance phenotypes and clinical distribution characteristics of clinically isolated carbapenem-resistant Klebsiella pneumoniae(CRKP),and provide evidence for rational use of antimicrobial agents and control of healthcare-associated infection(HAI). Methods CRKP isolated from inpatients in a hospital in 2013-2015 were collected,sources of specimens and homology of antimicrobial susceptibility of pathogens were analyzed. Results Of 949 non-repetitive strains of Klebsiella pneumoniae,75 (7.90% )were CRKP strains. The detection rates of CRKP from 2013 to 2015 were 1.35% ,7.77% ,and 17.04% respectively,which showed an up-ward trend year by year,difference was statistically significant(P<0.01). The main infection sites of CRKP were respiratory tract and urinary tract,CRKP mainly distributed in intensive care unit(ICU),geriatrics and emergency departments. Susceptibility rates of CRKP to amikacin and trimethoprim/sulfamethoxazole were 57.33% and 48. 00% respectively. 22 (29.33% )cases of CRKP infection were community-acquired and 53 (70.67% )were health-care-associated infection. 18 (24.00% )cases died among 75 CRKP infected patients. According to drug resistance phenotype analysis,there were 5 clones of CRKP strains,mainly distributed in ICU,geriatrics and emergency de-partments.Conclusion The proportion of CRKP infection is increasing year by year,clinical monitoring on CRKP should be strengthened,intensive infection control measures should be tarken,so as to prevent and control the spread and prevalence of CRKP.关键词
肺炎克雷伯菌/耐碳青霉烯类肺炎克雷伯菌/耐药表型/耐药性/抗药性,微生物/同源性Key words
Klebsiella pneumoniae/carbapenem-resistant Klebsiella pneumoniae/drug resistance phenotype/drug resistance/microbial/homology分类
医药卫生引用本文复制引用
孙晔佳,顾克菊..某院耐碳青霉烯类肺炎克雷伯菌检出与耐药表型分布[J].中国感染控制杂志,2017,16(2):130-133,137,5.基金项目
上海中医药大学校级医院管理研究项目(2016YG16) （2016YG16）
