中国康复理论与实践2017，Vol.23Issue(2)：162-165,4.DOI:10.3969/j.issn.1006-9771.2017.02.009
深部脑磁刺激术对慢性束缚应激大鼠习得性无助样绝望行为的疗效
Effect of Deep-brain Magnetic Stimulation on Learned Helplessness Behavior in Rats with Chronic Restrained Stress
摘要
Abstract
Objective To explore the curative effect of deep-brain magnetic stimulation (DMS) on learned helplessness behavior in the chronic restrained stress (CRS) rat model. Methods Twenty-nine Sprague-Dawley rats were randomly divided into control group (n=8) and CRS group (n=21). CRS group was exerted chronic restrained stress, while the control group did not receive any stress, for three weeks. Then learned helplessness behavior was tested using Forced Swimming Test (FST) and the hopeless rats of the CRS group were divided ran-domly into sham group (n=6), DMS group (n=8) and citalopram group (n=7), that received corresponding treatment respectively. They were evaluated with FST again after one-week treatment. Results The immobile time in FST was longer in CRS group than in the control group after three-week stress (F=11.260, P=0.002). After one-week treatment, no significant improvement was found in the citalopram group (F=1.565, P=0.235), however, the immobile time in DMS group decreased (F=6.277, P=0.025), and was shorter than that in the sham group (F=5.560, P=0.036). Conclusion CRS could result in learned helplessness behavior, which could be alleviated with one-week DMS.关键词
慢性束缚应激/习得性无助样绝望行为/深部脑磁刺激/绝望/自杀/抑郁/大鼠Key words
chronic restrained stress/learned helplessness behavior/deep-brain magnetic stimulation/hopelessness/suicide/depres-sion/rats分类
医药卫生引用本文复制引用
刘博,张攀,李达,杨予涛,郑云峰,徐志卿..深部脑磁刺激术对慢性束缚应激大鼠习得性无助样绝望行为的疗效[J].中国康复理论与实践,2017,23(2):162-165,4.基金项目
1.国家自然科学基金面上项目(No.81671345 （）
No.31171032 （）
No.31271154) （）
2.北京市自然科学基金重点项目(No.7091002) （No.7091002）
3.北京市自然科学基金重点B类项目(No.KZ201610025026). （No.KZ201610025026）
