中国药房2017，Vol.28Issue(6)：742-745,4.DOI:10.6039/j.issn.1001-0408.2017.06.06
紫杉醇联合顺铂、氟尿嘧啶经留置肝动脉导管给药用于胃癌肝转移的临床观察
Clinical Observation of Paclitaxel Combined with Cisplatin and Fluorouracil for Gastric Cancer with Liver Metastases via Indwelling Hepatic Arterial Catheter
摘要
Abstract
OBJECTIVE:To observe the efficacy and safety of paclitaxel combined with cisplatin and fluorouracil for gastric cancer with liver metastases via indwelling hepatic arterial catheter. METHODS:56 gastric cancer patients with liver metastases were randomly divided into control group(28 cases)and observation group(28 cases). Control group received Paclitaxel injection 135 mg/m2,d1+Cisplatin injection 75 mg/m2,d1+Fluorouracil injection 750 mg/m2,d1-5,pumping administrated via central venous. Ob-servation group received Paclitaxel injection 135 mg/m2,d1+Cisplatin injection 75 mg/m2,d1+Fluorouracil injection 750 mg/m2,d1-5, administrated via indwelling hepatic arterial catheter. 3-4 weeks were a course,it lasted 8 courses at most. Magnesium isoglycyrrhiz-inate injection 200 mg/d was intravenously infused for liver protection in 2 groups during treatment. Clinical efficacy,serum car-cinoembryonic antigen (CEA),alanine aminotransferase (ALT),aspartate aminotransferase (AST) levels before and after treat-ment,and the incidence of adverse reactions in 2 groups observed. RESULTS:Short-term clinical efficacy in observation group was significantly higher than control group,with statistical significance(P<0.01). Before treatment,there were no significant dif-ferences in CEA,ALT and AST levels(P>0.05). After treatment,CEA,ALT and AST levels in 2 groups were significantly high-er than before,ALT and AST levels in observation group were significantly higher than control group,while CEA level in observa-tion group was lower than control group,with statistical significances(P<0.05). The incidences of bone marrow suppression,nau-sea,vomiting and fever in observation group were significantly lower than control group,with statistical significances (P<0.05). CONCLUSIONS:Paclitaxel combined with cisplatin and fluorouracil has good efficacy for gastric cancer with liver metastases via indwelling hepatic arterial catheter,while it exists liver dysfunction.关键词
紫杉醇/顺铂/氟尿嘧啶/留置肝动脉导管/胃癌肝转移/疗效/安全性/肝功能Key words
Paclitaxel/Cisplatin/Fluorouracil/Indwelling hepatic arterial catheter/Gastric cancer with liver metastases/Effi-cacy/Safety/Live function分类
医药卫生引用本文复制引用
胡彦辉,崔庆丽,马东阳,王怀璋..紫杉醇联合顺铂、氟尿嘧啶经留置肝动脉导管给药用于胃癌肝转移的临床观察[J].中国药房,2017,28(6):742-745,4.基金项目
河南省医学科技攻关计划项目(No.201304099) （No.201304099）
