中国药房2017，Vol.28Issue(6)：745-748,4.DOI:10.6039/j.issn.1001-0408.2017.06.07
氟伐他汀联合阿司匹林对糖尿病性下肢动脉硬化闭塞症患者相关指标的影响
Effects of Fluvastatin Combined with Aspirin on the Related Indicators of Patients with Diabetic Lower Ex-tremity Arteriosclerosis Occlusive Desease
摘要
Abstract
OBJECTIVE:To investigate the effects of fluvastatin combined with aspirin on the related indicators of patients with diabetic lower extremity arteriosclerosis occlusive desease(LEAOD). METHODS:80 patients with diabetic LEAOD were ran-domly divided into control group(40 cases)and observation group(40 cases). Based on convertional treatment,control group was given Rosuvastatin calcium tablet 5 mg+Aspirin enteric-coated tablet 100 mg every evening;observation group was given Fluvas-tatin sodium capsule 40 mg+Aspirin enteric-coated tablet 100 mg. They were treated for 3 months. Fibrinogen,plasma D-dimer, blood viscosity, cholesterol (TC), triglyceride (TG), glycosylated hemoglobin (HbAlc), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), carotid intima-media thickness, compliance situation of TC, TG, HbAlc,LDL-C and HDL-C,cases of carotid intima thickening,plaque formation,stenosis and occlusion before and after treat-ment were observed,and the incidence of adverse reactions was recorded. RESULTS:After treatment,fibrinogen,plasma D-di-mer,blood viscosity,TC,TG,HbAlc,LDL-C and carotid intima-media thickness in 2 groups were significantly lower than before treatment,and observation group was significantly lower than control group;HDL-C in 2 groups was significantly higher than be-fore,and observation group was significantly higher than control group,with statistical significance (P<0.05). Compliance rates of TC,TG,LDL-C and HDL-C in observation group were significantly higher than control group,proportion of carotid intima thickening and carotid plaque formation were significantly less than control group,with statistical significance (P<0.05),there were no significant differences in the compliance rate of HbA1c,proportion of carotid stenosis and occlusion and the incidence of adverse reactions in 2 groups(P>0.05). CONCLUSIONS:Fluvastatin combined with aspirin can significantly improve the pa-tients 'blood viscosity,blood lipid,vascular endothelial function in the treatment of diabetic LEAOD,it can reduce the thrombotic disease risk,and does not increase the incidence of adverse reactions.关键词
氟伐他汀/阿司匹林/糖尿病性下肢动脉硬化闭塞症/血脂/内皮功能Key words
Fluvastatin/Aspirin/Diabetic lower extremity arteriosclerosis occlusive disease/Blood lipid/Endothelial function分类
医药卫生引用本文复制引用
康震,王宁,王芳,姚华强..氟伐他汀联合阿司匹林对糖尿病性下肢动脉硬化闭塞症患者相关指标的影响[J].中国药房,2017,28(6):745-748,4.基金项目
邯郸市科学技术研究与发展计划项目(No.1328108089-2) （No.1328108089-2）
