中国药房2017，Vol.28Issue(6)：749-752,4.DOI:10.6039/j.issn.1001-0408.2017.06.08
奥沙利铂、丝裂霉素和多柔比星联合三维适形放疗用于乏血供肝癌的临床观察
Clinical Observation of Oxaliplatin,Mitomycin and Doxorubicin Combined with Three-dimensional Con-formal Radiotherapy for Patients with Lack of Blood Supply Hepatocellular Carcinoma
摘要
Abstract
OBJECTIVE:To observe the efficacy and safety of oxaliplatin,mitomycin and doxorubicin combined with three-di-mensional conformal radiotherapy for patients with lack of blood supply hepatocellular carcinoma. METHODS:62 patients with lack of blood supply hepatocellular carcinoma who lose the opportunity of operation were randomly divided into control group(31 cas-es)and observation group(31 cases). Control group received puncture through the femoral artery by Seldiner,selectively interven-ing in hepatic arteries for DSA angiography,then intravenously injected 130 mg/m2 Oxaliplatin for injection via the catheter,once every 2 weeks+Mitomycin for injection 10 mg,intravenously,once every 1-3 week(s)+Doxorubicin for injection 1.2 mg/kg,once every 3 weeks,then giving Iodinated oil emulsifier and Gelatin sponge particle for hepatic artery embolization,appropriate Iodinat-ed oil emulsifier and Gelatin sponge particle once a month,for 3 times. Observation group was additionally received three-dimen-sional conformal radiotherapy 2 Gy,for 25-30 times with total dose of 50-60 Gy,once every 3 days. They were treated for 3-month. Clinical efficacy,the survival rate and median survival time after the first administration of drug for 1,2 and 3 years in 2 groups were observed,and the incidence of adverse reactions was recorded. RESULTS:The total effective rate,the survival rate and median survival time in 1,2 and 3 years in observation were significantly higher than control group,with statistical signifi-cance (P<0.05). The incidences of neutropenia,thrombocytopenia,hemoglobin decreased and radioactive disease in observation group were significantly higher than control group,with statistical significances(P<0.05). CONCLUSIONS:Oxaliplatin,mitomy-cin and doxorubicin combined with three-dimensional conformal radiotherapy have good efficacy for patients with hepatocellular lack of blood supply carcinoma,also can prolong the survival time,they show poor safety.关键词
乏血供肝癌/奥沙利铂/丝裂霉素/多柔比星/肝动脉化疗栓塞/三维适形放疗/疗效/安全性Key words
KEYWORDS Lack of blood supply hepatocellular carcinoma/Oxaliplatin/Mitomycin/Doxorubicin/TACE/Three-dimensional conformal radiotherapy/Efficacy/Safety分类
医药卫生引用本文复制引用
陈鲁青,高志强,程会云,孙振友,高洪盛,贺光辉,赵允正..奥沙利铂、丝裂霉素和多柔比星联合三维适形放疗用于乏血供肝癌的临床观察[J].中国药房,2017,28(6):749-752,4.基金项目
潍坊市卫生局科研项目(No.〔2014〕第161号) （No.〔2014〕第161号）
