中国药房2017，Vol.28Issue(6)：752-755,4.DOI:10.6039/j.issn.1001-0408.2017.06.09
苦参膜与rhEGF凝胶分别联合云南白药用于宫颈LEEP术后创面的临床观察
Clinical Observation of Oxymatrine Membrane,rhEGF Gel Combined with Yunnan Baiyao for Postopera-tive Cervical Wound after LEEP
摘要
Abstract
OBJECTIVE:To explore the clinical efficacy and safety of oxymatrine membrane,rhEGF gel respectively com-bined with Yunnan baiyao for postoperative cervical wound after LEEP. METHODS:300 patients with cervical intraepithelial neo-plasia(CIN)Ⅱ and Ⅲ were divided into group A,B,C(100 cases in each group)based on CIN grading and stratification and random sampling in each stratification. After conventional LEEP,patients in group A were cleaned the wound by 0.9% Sodium chloride injection,spraying Yunnan baiyao powder,once only after surgery;patients in group B were additionally given recombi-nant human epidermal growth factor (rhEGF) on the basis of group A,once every week after surgery,for 3 weeks;patients in group C were additionally given oxymatrine membrane on the basis of group A,1 tablet every evening after surgery,for 2 weeks. Postoperative bleeding,bleeding duration,rebleeding and duration after postoperative bleeding stopped,postoperative drainage du-ration,the incidence of adverse reactions in 3 groups were observed. RESULTS:The patients of postoperative bleeding,bleeding time ≥7 d and rebleeding after stopping bleeding in group B were significantly lower than group A;the incidence of bleeding time ≥7 d in group C was significantly lower than group A,the proporition of postoperative drainage duration for less than 7 d was significantly higher than group A,for 8-13 d was significantly less than group A;early wound healing rate in group B and group C were significantly better than group A,with statistical significances (P<0.05). There were no significant differences in above-mentioned indexes in group B and group C(P>0.05),and there were no obvious adverse reactions in 3 groups. CONCLU-SIONS:Oxymatrine membrane and rhEGF gel respectively combined with Yunnan baiyao have better healing than Yunnan baiyao alone,do not increase the incidence of adverse reactions,while there is no significant difference in oxymatrine membrane and rhEGF gel.关键词
宫颈环形电切术/云南白药/重组人表皮生长因子/苦参膜/创面Key words
LEEP/Yunnan baiyao/rhEGF gel/Oxymatrine membrane/Wound分类
医药卫生引用本文复制引用
缪雪阳,夏同霞,缪炜烈,陈大勇,付立仙,孙颖..苦参膜与rhEGF凝胶分别联合云南白药用于宫颈LEEP术后创面的临床观察[J].中国药房,2017,28(6):752-755,4.基金项目
遵义市科技计划课题(No.遵市科合社字〔2014〕69号) （No.遵市科合社字〔2014〕69号）
