摘要
Abstract
Objective To compare the clinical effect between thoracoscopic lung cancer radical resection and thoracotomy in the treatment of early non-small cell lung cancer (NSCLC). Method 107 cases of early NSCLC patients from October 2009 to February 2015 in our hospital were divided into thoracoscope group (n = 54) and thoracotomy group (n = 53) according to the random number table. Patients in thoracoscope group were treated with thoracoscopic lung cancer radical resection, patients in thoracotomy group were treated with thoracotomy. Patients of the two groups were taken with systemic lymphadenectomy. Operative time, blood loss, number of lymph node dissection, postoperative drainage time, visual analogue scale (VAS) score, postoperative activity time, postoperative hospital stay, immunologic function, incidence of postoperative complications, 1 year survival rate and 3 years survival rate between the groups were compared. Result There were no significant differences in the operative time and total retrieved lymph nodes between the two groups (P > 0.05). The blood loss in thoracoscope group was less than thoracotomy group (P < 0.01), postoperative drainage time, postoperative activity time and postoperative hospital stays of thoracoscope group were all shorter than those of thoracotomy group (P < 0.01), postoperative VAS scores were lower than thoracotomy group (P < 0.01). 1 day, 3 days and 7 days after operation, the levels of CD3+, CD4+, CD8+, CD4+/CD8+ and NK cells of thoracoscope group were higher than those of thoracotomy group at the same time (P < 0.05); the incidence rate of postoperative complications of thoracoscope group was lower than thoracotomy group (P < 0.05), there were no significant differences in 1 year survival rate and 3 years survival rate between the two groups (P > 0.05). Conclusion In the treatment of early NSCLC,thoracoscope not only can achieve the same postoperative survival rate and lymph node cleaning effect as the thoracotomy, and has the advantage of less trauma, faster, recovery, lighter immunosuppression and lower incidence rate of postoperative complications at the same time.关键词
非小细胞肺癌/胸腔镜/肺癌根治术/免疫抑制Key words
Non-small cell lung cancer/Thoracoscope/Radical resection of pulmonary carcinoma/Immu-nosuppression
