摘要
Abstract
Objective To investigate the effect of intensive hemoperfusion combined with methylpredn-isolone sodium succinate on pulmonary fibrosis and serum paraquat clearance in patients with acute paraquat poisoning, and to observe its clinical curative effect. Method 58 patients with acute paraquat poisoning from February 2010 to February 2016 in our hospital were divided into experimental group and control group by completely randomized method. Patients in both groups were treated with routine therapy, such as blockage of poison absorption and promotion of toxic excretion, and intensive hemoperfusion treatment, while experimental group patients were given methylprednisolone succinate treatment. Paraquat concentration was determined by before treatment (Tpre), immediately after treatment (T0), 8 hours after treatment (T8), 16 hours after treatment (T16) respectively to calculate the clearance. High-resolution computed tomography (HRCT) score and levels of serum hyaluronic acid (HA) and matrix metalloproteinase-9 (MMP-9) were used to assess the degree of pulmonary fibrosis in 1 day, 3 days, 7 days and 14 days after treatment. The survival rates of the two groups were compared. Result The clearance rate of T0 in experimental group was significantly higher than that in control group (P < 0.05), and there were no differences in T0 and T16 (P > 0.05). The HRCT score, levels of HA and MMP-9 of the two groups increased gradually after treatment, but experimental group increased slower (P < 0.05). The survival rate of experimental group was significantly higher than that of control group (P < 0.05). Conclusion The combination of intensive hemoperfusion and methylprednisolonesodium succinate can significantly improve the paraquat clearance rate, relieve the degree of pulmonary fibrosis and improve the survival rate of patients with acute paraquat poisoning. It is worthy of popularization and application.关键词
强化血液灌流/甲泼尼龙琥珀酸钠/冲击治疗/百草枯中毒/肺纤维化Key words
Intensive hemoperfusion/Methylprednisolone sodium succinate/Shock therapy/Paraquat poisoning/Pulmonary fibrosis
