组织工程与重建外科杂志2017，Vol.13Issue(1)：25-28,4.DOI:10.3969/j.issn.1673-0364.2017.01.007
iRGD-外泌体-阿霉素抑制恶性黑色素瘤体外增殖的研究
The Inhibition of iRGD-Exosomes-Doxorubicin on the Proliferation of Malignant Melanoma in Vitro
赵莉娟 1郑江红 1柳向东 1茅广宇 1邓辰亮 1杨松林1
作者信息
- 1. 200233 上海市 上海交通大学附属第六人民医院整形外科
- 折叠
摘要
Abstract
Objective To investigate the effect and targeting of iRGD-exosomes-doxorubicin (iRGD-exo-dox) on the inhibition of A375 cell line. Methods The exosomes were extracted from the iRGD-transfected A375 cells. The doxorubicin was wrapped by electroporation. Flow cytometry was used to detect the affinity of iRGD-exo-dox to A375 cells. The ability of iRGD-exo-dox on inhibiting the proliferation of A375 cells was analyzed. Results The affinity of iRGD-exo-dox to A375 cells was higher than the blank-exo-dox. The proliferation of A375 cells was obviously inhibited by iRGD-exo-dox. The inhibition effect was not observed in blank-exo-dox group. Conclusion iRGD-exo-dox can inhibit the proliferation of A375 cells by targeting function.关键词
恶性黑色素瘤/靶向治疗/外泌体/阿霉素Key words
Malignant melanoma/Targeted therapy/Exosome/Doxorubicin分类
医药卫生引用本文复制引用
赵莉娟,郑江红,柳向东,茅广宇,邓辰亮,杨松林..iRGD-外泌体-阿霉素抑制恶性黑色素瘤体外增殖的研究[J].组织工程与重建外科杂志,2017,13(1):25-28,4.
