组织工程与重建外科杂志2017，Vol.13Issue(1)：29-33,5.DOI:10.3969/j.issn.1673-0364.2017.01.008
中小剂量地塞米松预防下肢急性创伤后软组织早期并发症的临床研究
Small and Medium Dose of Dexamethasone on Prevention of Early Complications of Soft Tissue after Acute Trauma in Lower Extremity
摘要
Abstract
Objective To investigate the clinical effect of small and medium dose of dexamethasone on prevention of early complications of soft tissue after acute trauma in lower extremity. Methods From January 2015 to March 2016, 350 patients with acute trauma in lower extremity were selected by using simple sampling method. All the patients were divided into 3 groups through a simple randomization, 116 cases in the control group, 116 cases in the small dose group, 117 cases in the medium dose group. All patients were treated with basic treatment, then the control group were treated with glucose infusion by intravenous injection, small dose group were treated with dexamethasone (0.1 mg/Kg) infusion by intravenous injection, medium dose group were treated with dexamethasone (0.2 mg/Kg) infusion by intravenous injection. The difference of limb blister incidence, limb circumference ratio, IL-6, CRP, osteofascial compartment syndrome occurred rate and adverse reaction rate among the three groups were compared. Results Limb circumference ratio of small dose group and medium dose group at 48 h were significantly less than that before treatment (P<0.05), and were both significantly less than that of the control group (P<0.05). But the difference between small dose group and medium dose groups had no statistical significance (P>0.05). The level of CRP and IL-6 at 48 h in small dose group and medium dose group were significantly lower than that before treatment (P<0.05), and was significantly lower than that in control group (P<0.05), and the IL-6 and CRP levels in the middle dose group were significantly lower than those in the small dose group (P<0.05). The limb blister incidence, osteofascial compartment syndrome incidence rate of small dose group and middle dose group were significantly lower than that of the control group (P<0.05). But there was no statistical significance between small dose group and medium dose group (P>0.05). The adverse reaction among the three groups had no statistical significance ( P>0.05). Conclusion The rate of early complications of soft tissue after acute trauma of lower extremity can be effectively reduced by application of small and medium dose of dexamethasone. However, application of medium dose of dexamethasone can not increase the patient's clinical effect.关键词
中小剂量/地塞米松/下肢急性创伤/软组织早期并发症Key words
Small and medium dose/Dexamethasone/Acute trauma of lower extremity/Early complications of soft tissue分类
医药卫生引用本文复制引用
冯宇,张睿,张玲,信维伟..中小剂量地塞米松预防下肢急性创伤后软组织早期并发症的临床研究[J].组织工程与重建外科杂志,2017,13(1):29-33,5.基金项目
上海市卫生与计划生育委员会科研课题面上项目(201440605). （201440605）
