癌变·畸变·突变2017，Vol.29Issue(2)：87-90,95,5.DOI:10.3969/j.issn.1004-616x.2017.02.002
结直肠癌组织中KIAA1522的表达 及临床意义
Significance in expression of KIAA1522in colorectal cancer
摘要
Abstract
OBJECTIVE:To investigateexpression status of KIAA1522 in colorectal cancer (CRC),and its correlation with clinicopathological features and prognosis. METHODS:Expression of KIAA1522 protein was determined with tissue microarrays-immunohistochemistry (TMA-IHC) technique in surgically-resected colorectal cancer tissues and adjacent normal epithelia from 96 patients. The relationship between KIAA1522expressionand clinicopathological characteristics and prognosis of the patients were analyzed.RESULTS:KIAA1522 protein was mainly localized in the cytoplasm of colorectal epithelial cells. While only 12.5% (12/96) of normal colorectal epithelia displayed positive staining,81.3% (78/96) of CRC specimens showed over-expression of KIAA1522. The difference between them was highlysignificant (P<0.001). Kaplan-Meier survival analysis revealed that high level of KIAA1522 expression was correlated with lower 3-year disease free survival (DFS) rate of CRC patients (P=0.017). Furthermore,KIAA1522 up-regulation was significantly correlated with distant metastasis (P=0.012). More importantly,Cox regression analysis indicated that KIAA1522 protein expression was an independent prognosis factor in CRC (P=0.020).CONCLUSION:KIAA1522 was frequently up-regulated in CRC,and its over-expression was significantly correlated with distant metastasis and poor prognostic,thus KIAA1522 over-expression may served as a new prognostic marker in colorectal cancer.关键词
结直肠癌/KIAA1522/转移/预后Key words
colorectal cancer/KIAA1522/metastasis/prognosis分类
医药卫生引用本文复制引用
刘婷婷,张钰,梁建伟,余竟,常晨,王明荣,郝佳洁,周志祥,蔡岩,张彤彤..结直肠癌组织中KIAA1522的表达 及临床意义[J].癌变·畸变·突变,2017,29(2):87-90,95,5.基金项目
国家自然科学基金面上项目(81472562) （81472562）
国家重点研发计划项目精准医学研究专项(2016YFC0905300) （2016YFC0905300）
