癌变·畸变·突变2017，Vol.29Issue(2)：102-105,4.DOI:10.3969/j.issn.1004-616x.2017.02.005
Syntenin在 非小细胞肺癌中的表达及其与患者总生存期的关系
Expression of Syntenin in non-small cell lung cancer tissues and its relationship with overall survival of patients
摘要
Abstract
OBJECTIVE:The aim of this study was to detect the expression of Syntenin in non-small cell lung cancer (NSCLC) tissues and to explore its clinical significance.METHODS:We detected expression of Syntenin in 147 NSCLC tissues and 147 para-carcinoma tissues by tissue microarray and immunohistochemical staining method,and analyzed the relationship of Syntenin expression with clinicopathological parameters and prognosis of NSCLC patients. RESULTS:Expression level of Syntenin (positive rate 49.7%) in NSCLC tissues was significantly higher than that in adjacent lung tissues (positive rate 4.1%,P<0.01). Over-expression of Syntenin was associated with lymph node metastasis,clinical stage and pathological type in NSCLC patients (P=0.039,P=0.038 andP=0.024),but not with age or gender. The Kaplan-Meier survival analysis revealed that Syntenin expression in primary tumors was significantly associated with patients' overall survival (P=0.028). CONCLUSION:Syntenin protein was over-expressed in NSCLC tissues,and was associated with poor prognosis of patients.关键词
Syntenin/非小细胞肺癌/淋巴结转移/总生存期Key words
Syntenin/non-small cell lung cancer/lymph node metastasis/overall survival分类
医药卫生引用本文复制引用
宋杰,李萍,于雪新,冯林,高燕宁,肖汀..Syntenin在 非小细胞肺癌中的表达及其与患者总生存期的关系[J].癌变·畸变·突变,2017,29(2):102-105,4.基金项目
协和青年基金(3332016032) （3332016032）
