癌变·畸变·突变2017，Vol.29Issue(2)：106-110,120,6.DOI:10.3969/j.issn.1004-616x.2017.02.006
贲门腺癌中Sox17蛋白表达及其与β-catenin、cyclin D1蛋白相关性研究
Expression of Sox17 protein and correlation with β-catenin and cyclin D1 protein in gastric cardia adenocarcinoma
摘要
Abstract
OBJECTIVE:To investigate expression of Sox17,β-catenin and cyclin D1 proteins in gastric cardia adenocarcinoma(GCA),and to establish their relationship with pathogenesis of GCA.METHODS: Immunohistochemistry method was applied to examine the expression of Sox17,β-catenin and cyclin D1 proteins in 78 samples of GCA and the corresponding adjacent non-cancerous tissues.RESULTS:In GCA tissues,the frequency of Sox17,β-catenin and cyclin D1 expression was 47.4% (37/78),83.3% (65/78) and 70.5%(55/78),respectively, which was significantly lower than that in corresponding adjacent non-cancerous tissues:69.2%(54/78),62.8%(49/78) and 44.9%(35/78),(P<0.01). The frequency of β-catenin ectopic expression was 83.3%(65/78) in GCA tissues which was significantly higher than that in corresponding adjacent non-cancerous tissues of 62.8%(49/78) (P<0.01). Sox17 expression was negatively correlated with ectopic expression ofβ-catenin and cyclin D1 (r=-0.264,P<0.05;r=-0.287,P<0.05). Sox17 were significantly correlated with tumor stage (P=0.045).β-catenin and cyclin D1 were significantly correlated with lymph node metastasis(P<0.05). CONCLUSION:Low level expression of Sox17 protein may play an important role in the development of GCA via aberrantly activating the canonical Wnt/β-catenin signaling pathway through influencing the expression ofβ-catenin and cyclin D1.关键词
Sox17/β-catenin/cyclinD1/Wnt信号转导通路/贲门腺癌Key words
Sox17/β-catenin/cyclin D1/Wntsignalpathway/gastric cardia adenocarcinoma分类
医药卫生引用本文复制引用
潘盼,邝钢,郭艳丽,郭炜,董稚明,杨飞..贲门腺癌中Sox17蛋白表达及其与β-catenin、cyclin D1蛋白相关性研究[J].癌变·畸变·突变,2017,29(2):106-110,120,6.基金项目
河北省自然科学基金(H2013206315) （H2013206315）
河北省医学科学研究重点课题计划项目(20130543) （20130543）
