癌变·畸变·突变2017，Vol.29Issue(2)：111-114,4.DOI:10.3969/j.issn.1004-616x.2017.02.007
锶在兔体内 部分组织器官分布 与富集规律的 模拟研究
Simulation study on the distribution and accumulation of strontium in some organs of rabbits
摘要
Abstract
OBJECTIVE:We used the Japanese big-ear rabbits to study the distribution and accumulation of strontium in their different organs.METHODS:24 Japanese big-ear rabbits were randomly allocated into one blank group and five experimental groups. Rabbits of the blank group (group 1) were fed with deionized water while the experimental group were fed with deionized water plus the addition of strontium chloride hexahydrate every other day. The concentration of strontium chloride was 0.002 g/mL. The volume of water with strontium that was given to the rabbits from groups 2 to 6 were 1,2,3,4 and 5 mL respectively. After 30 days of oral treatment,samples of blood,liver and back leg tibialis were taken. All samples were dried,mashed and decompounded by nitric acid. The concentration of strontium was analyzed by inductively coupled plasma atomic emission spectrometry (ICP-AES).RESULTS:Plasma strontium concentrations in rabbits positively related to oral treatment dose with strontium chloride. R2 of linear fitting method was 0.82. Liver strontium concentrations in rabbits showed no significant correlation with oral treatment dose. Back leg tibialis strontium concentrations in rabbits positively related to oral treatment dose with strontium chloride. R2 of linear fitting method was 0.98. Plasma strontium concentrations positively related to back leg tibialis strontium concentrations. R2 of linear fitting method was 0.76.CONCLUSION:Strontium was absorbed by the body from the gut,transferred through plasma and concentrated in bone.关键词
锶/骨骼/血液/日本大耳白兔/富集Key words
strontium/bone/plasma/Japanesebig-ear rabbit/concentration分类
医药卫生引用本文复制引用
何映雪,闫冬,丁库克,姜晓燕..锶在兔体内 部分组织器官分布 与富集规律的 模拟研究[J].癌变·畸变·突变,2017,29(2):111-114,4.基金项目
国家自然科学基金面上项目(41672228) （41672228）
