癌变·畸变·突变2017，Vol.29Issue(2)：115-120,6.DOI:10.3969/j.issn.1004-616x.2017.02.008
维吾尔族霍奇金淋巴瘤与HLA-DRB1、DPA1基因多态性的相关性研究
HLA-DRB1 and DPA1 gene polymorphisms in Hodgkin's lymphoma of Uighurs
摘要
Abstract
OBJECTIVE:To explore the relationship between the human leukocyte antigen (HLA)DRB1,DPA1 low resolution type alleles and susceptibility of Uighurs to develop Hodgkin's lymphomas (HL).METHODS:Using a case-control study design,DNA direct sequencing classification method (SBT) was used to detect alleles inHLA-DRB1 and expression ofHLA-DPA1 gene among 40 cases of Uighur patients and 80 healthy controls. TheHLA-DRB1 andDPA1 allele frequencies between the two groups were compared. The correlation between them with the pathogenesis of HL was analyzed.RESULTS:HLA-DRB1 andDPA1 low resolution alleles were detected 12,3 types in the case group and 13,4 types in the control group,the frequency distribution of which met the Hardy-Weninberg genetic balance test (P>0.05). The results show thatHLA-DRB1*15,DPA1*03 andDPA1*02-DRB1*13 gene frequencies were significantly more frequent in the Uighur patients than the controls (P=0.016,OR=3.476;P=0.002,OR=4.248;P=0.037,OR=3.028, respectively);HLA-DRB1*07 gene frequencies between the two groups were statistically significant (P=0.025, OR=0.314). CONCLUSION:HLA-DRB1,DPA1 gene polymorphism may be closely associated with the onset ofHL among Uighurs and with pathogenesis of HL.关键词
霍奇金淋巴瘤/维吾尔族/人类白细胞抗原/基因频率Key words
Hodgkin's lymphoma/Uygur/human leukocyte antigen/gene frequency分类
医药卫生引用本文复制引用
张海燕,李迅..维吾尔族霍奇金淋巴瘤与HLA-DRB1、DPA1基因多态性的相关性研究[J].癌变·畸变·突变,2017,29(2):115-120,6.基金项目
新疆自治区优秀青年科技创新人才培养项目(2014721044) （2014721044）
