癌变·畸变·突变2017，Vol.29Issue(2)：121-124,4.DOI:10.3969/j.issn.1004-616x.2017.02.009
长链非编码RNA XIST和miR-101-3p在子宫颈癌组织中的表达及关系
Expressionof LncRNA XIST and miR-101-3p in cervical cancer
刘平1
作者信息
- 1. 南阳市第二人民医院妇产科,河南 南阳 473012
- 折叠
摘要
Abstract
OBJECTIVE:To investigate the expression and clinical significance of long non-coding RNA (LncRNA) XIST and miR-101-3p in cervical cancer. METHODS:Cervical cancer tissues and matched non-tumor para-neoplastic tissues were collected from 58 patients. Quantitative real-time PCR was used to examine the expressionof LncRNA XIST and miR-101-3p,the correlation between them and their correlation with clinicopathological features were analyzed.RESULTS:LncRNA XIST expression was significantly up-regulated in cervical cancer tissues than in adjacent non-tumor tissues (P<0.05). The expression of miR-101-3p was significantly down-regulated in cervical cancer tissues as compared with the adjacent tissues (P<0.05).The expression of them in nucleic acid levels were negatively correlated(r=-0.68,P =0.000)and correlated significantly with FIGO stage,lymph node metastasis,and tissue size of tumor (P<0.05). CONCLUSION:Our findings indicate that LncRNA XIST and miR-101-3p may be potential prognostic markers and therapeutictargets for cervical cancer. The expression of LncRNA XIST and miR-101-3pwas negatively correlated.关键词
宫颈癌/LncRNAXIST/miR-101-3p/淋巴结转移Key words
cervical cancer/LncRNA XIST/miR-101-3p/lymphnode metastasis分类
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刘平..长链非编码RNA XIST和miR-101-3p在子宫颈癌组织中的表达及关系[J].癌变·畸变·突变,2017,29(2):121-124,4.
