癌变·畸变·突变2017，Vol.29Issue(2)：139-142,4.DOI:10.3969/j.issn.1004-616x.2017.02.013
DKK1在食管胃结合部腺癌患者血清中的水平及其临床诊断价值
Serum level and clinical diagnostic value of DKK1 in adenocarcinoma at the esophago-gastric junction
摘要
Abstract
OBJECTIVE:To study the serum level and diagnostic value of Dickkopf-1(DKK1) in patients with adenocarcinoma at the esophago-gastric junction (AEGJ). METHODS:Serum levels of DKK1 in 79 patients with AEGJ and 101 normal controls were measured by enzyme-linked immunosorbent assay (ELISA). Receiver operating characteristics (ROC) was used to calculate its diagnostic value.RESULTS:The serum levels of DKK1 were significantly higher in AEGJ than in normal controls (P=0.001). ROC curves showed that the optimum diagnostic cutoff for serum DKK1 was 2615.9 pg/mL,providing an area under the curve (AUC) of 0.650 (95%CI:0.569-0.731),a sensitivity/specificity of 34.2%/95.0%. Moreover,serum DKK1 had early diagnostic value for AEGJ [AUC 0.674 (95%CI:0.521-0.827)],35.7% sensitivity and 96.0% specificity. Moreover,the positive rate of DKK1 was not significantly related to age,gender,size of tumor,depth of tumor invasion,lymph node status,or TNM stage (P>0.05),but related to distant metastasis (P<0.05).CONCLUSION:Serum levels of DKK1 was high in AEGJ patients which indicates that serum DKK1 may be a potential biomarker for early diagnosis of AEGJ.关键词
DKK1/肿瘤标志物/食管胃结合部腺癌/诊断Key words
DKK1/tumor marker/adenocarcinoma of esophago-gastric junction/diagnosis分类
医药卫生引用本文复制引用
许镒洧,郭竑,郭海鹏,彭裕辉..DKK1在食管胃结合部腺癌患者血清中的水平及其临床诊断价值[J].癌变·畸变·突变,2017,29(2):139-142,4.基金项目
广东省科技计划项目(2013B021800250) （2013B021800250）
汕头大学医学院临床提升计划项目(201428) （201428）
