安徽医科大学学报2017，Vol.52Issue(2)：281-285,5.DOI:10.19405/j.cnki.issn1000-1492.2017.02.030
SIRT6在结直肠癌组织中的表达及其临床意义
Expression and clinical significance of SIRT6 in colorectal cancer
摘要
Abstract
Objective To explore the expression and the clinical significance of SIRT6 in colorectal cancer ( CRC) . Methods The expression levels of SIRT6 protein and mRNA in 29 samples of CRC and paired adjacent normal tissues were tested by Western blot and RT-qPCR. 113 paraffin samples ( including the former 29 samples) of CRC and adjacent tissues were detected by immunohistochemistry. The associated of expression levels of SIRT6 protein and clinical parameters were analyzed. Results The expression level of SIRT6 was significantly lower in CRC than in adjacent normal tissues( P<0. 05 ) . The expression level of SIRT6 was associated with differentiated degree, depth of invasive lymphatic metastasis and TNM stage (P<0. 05), whereas was not with other clinical pa-rameters. Conclusion The low expression of SIRT6 is involved in the tumorigenesis and progression of CRC. SIRT6 might play a role as tumor suppressor and can be regarded as a promising diagnostic and therapeutic target for CRC.关键词
SIRT6/结直肠癌/Westernblot/RT-qPCR/免疫组化Key words
SIRT6/colorectal cancer/Western blot/RT-qPCR/immunohistochemistry分类
医药卫生引用本文复制引用
齐佳,崔春晖,陈日红,翟端洋,王利峰,谢朗,俞金龙..SIRT6在结直肠癌组织中的表达及其临床意义[J].安徽医科大学学报,2017,52(2):281-285,5.基金项目
广东省自然科学基金(编号:2014A030313295) （编号:2014A030313295）
