波谱学杂志2017，Vol.34Issue(1)：52-60,9.DOI:10.11938/cjmr20170107
基于自主研发的500 MHz NMR谱仪的紫杉醇结构解析
Structure Elucidation of Taxol Based on Two-Dimensional NMR Spectra Collected on a 500 MHz NMR Spectrometer Built In-House
摘要
Abstract
A 500 MHz NMR spectrometer was successfully built in-house in Wuhan Institute of Physics and Mathematics in 2006, and it had been used for researches in many areas. However, the performance of this spectrometer in acquiring two-dimensional (2D) NMR spectra needed for structure elucidation had not been evaluated until now. In this paper, we acquired all the one-dimensional (1D) and 2D (i.e., 1H-1H COSY, 1H-1H TOCSY, J-Res, 1H-13C HMQC and 1H-13C HMBC) NMR spectra of taxol on this spectrometer, and used these spectra to elucidate the structure of the compound. The results showed that, with the spectra acquired on the 500 MHz NMR spectrometer built in-house, the structure of taxol could be elucidated correctly. We also corrected some incorrect NMR assignments of taxol existing in the literature.关键词
国产核磁共振谱仪(WIPM-I500型NMR谱仪)/二维核磁共振/结构归属/紫杉醇Key words
500 MHz NMR spectrometer built in-house (WIPM-I 500)/two-dimensional NMR/structure elucidation/taxol分类
数理科学引用本文复制引用
周琪,黄重阳,高珊,汪慧娟,冯继文,刘朝阳,张金枝,邹其超..基于自主研发的500 MHz NMR谱仪的紫杉醇结构解析[J].波谱学杂志,2017,34(1):52-60,9.基金项目
国家自然科学基金资助项目(11575287, 11405264),国家重大科学仪器设备开发专项(2011YQ120035). （11575287, 11405264）
