波谱学杂志2017，Vol.34Issue(1)：115-129,15.DOI:10.11938/cjmr20170114
固体核磁共振技术在骨基生物材料研究中的应用
Application of Solid-State NMR to Bone and Bone Biomaterials
摘要
Abstract
Bone, as a structural organization and an important hematopoietic organ of the human body, plays critical biological roles in protecting human organs, storing calcium and phosphorus, participating in metabolism regulation and providing attachment sites for muscles. Understanding the microstructure of bone is important for intervention and treatment of bone diseases. However, experimental characterizations of the bone has been hindered by the morphological diversity of the bone, coexistence of organic and inorganic components, and sensitivity of bone samples to physical and chemical treatment. Compared with other techniques, solid-state nuclear magnetic resonance (NMR) can study the bone in-situ without any chemical pretreatment, thus avoiding changing bone structure. In addition, most of the chemical elements in the bone are magnetic resonance detectable, such as 1H, 13C, 31P, 19F, 43Ca, 29Si, 25Mg and 87Sr. Therefore, high resolution solid-state NMR technique provides a powerful tool for structural studies of the bone and bone biomaterials. In this paper, we reviewed the recent progresses in the application of solid-state NMR to bone and bone biomaterials studies.关键词
固体核磁共振(solid-stateNMR)/骨头/羟基磷灰石/生物玻璃/生物矿化Key words
solid-state NMR/bone/hydroxyapatite/bioglass/biomineralization分类
数理科学引用本文复制引用
李东北,许帅,喻志武..固体核磁共振技术在骨基生物材料研究中的应用[J].波谱学杂志,2017,34(1):115-129,15.基金项目
国家自然科学基金资助项目(21203202). （21203202）
