磁共振成像2017，Vol.8Issue(3)：170-175,6.DOI:10.12015/issn.1674-8034.2017.03.003
IVIM多参数预测乳腺癌免疫组化指标表达的可行性研究
The feasibility of intravoxel incoherent motion to indicate immunohistochemical characteristics in breast cancer
摘要
Abstract
Objective:To explore the difference in apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) parameters (D, D*, and f) of breast cancer regarding the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and antigen identified by monoclonal antibody Ki-67.Materials and Methods:Patients suspected to be suffering from breast cancer and had undergone preoperative breast MRI with intravoxel incoherent motion diffusion-weighted imaging in our institution between November 2015 and February 2016 were included in this study. All MR imaging examinations were performed on a 3.0 T MRI scanner (Philips, Ingenia). The ADC values were calculated from DW images at all b-values, assuming monoexponential signal shape. IVIM parameters (D, D*, and f) were obtained using multi-b-value DWI with a biexponential curve fitting. ADC and IVIM parameters (D, D*, and f) of patients with different ER, PR, HER-2, or Ki-67 expression were compared to explore the relationships between MRI and immunohistochemical findings of patients with breast cancer.Results:Fifty-five breast cancer lesions (51 patients) with positive pathologic results were included in our study. Of the 55 lesions, the amount of ER positive, PR positive, HER-2 positive, and Ki-67 high-expression lesions were 45, 40, 14, and 36, respectively. Mean D values in the Ki-67 high-expression group were significantly lower than those in the Ki-67 low-expression group (0.80±0.16 vs 0.88±0.14,P=0.046), while no signiifcant differences were showed in ADC, D*, and f value between the two groups. No statistical signiifcance was reached regarding the difference in mean ADC value or IVIM parameters (D, D*, and f) between the groups with different ER, PR, or HER-2 expression.Conclusions:Statistical difference in D value of IVIM parameters was found between the two groups with different Ki-67 expression in breast carcinoma. This may indicate the potential to provide a surrogate measure of Ki-67 expression through noninvasive imaging tools.关键词
乳腺肿瘤/磁共振成像/免疫组织化学Key words
Breast neoplasms/Magnetic resonance imaging/Immunohistochemistry分类
医药卫生引用本文复制引用
宋萌萌,张天月,王丽君,罗冉,汪登斌..IVIM多参数预测乳腺癌免疫组化指标表达的可行性研究[J].磁共振成像,2017,8(3):170-175,6.基金项目
国家自然科学基金( 编号:81371621) （ 编号:81371621）
上海申康发展中心,临床辅助科室能力(影像学科)建设(编号:SHDC22015022) ACKNOWLEDGMENTS This work was supported by the fund of National Natural Science Foundation of China (No. 81371621) and Shanghai Shenkang Hospital Development Center (No. 22015022). （影像学科）
