重庆医学2017，Vol.46Issue(5)：626-627,2.DOI:10.3969/j.issn.1671-8348.2017.05.016
血红素加氧酶-1与一氧化碳在肺炎支原体感染患儿中的水平变化及其意义
Levels of heme oxygenase-1 and carbon monoxide and its significance in the Mycoplasma pneumoniae infection in children
陈小珍 1王继武 1何春枝1
作者信息
- 1. 华中科技大学同济医学院附属普爱医院儿科,武汉430034
- 折叠
摘要
Abstract
Objective To explore the heme oxygenase-1 (HO-1) content of carbon monoxide (CO) levels and clinical significance of Mycoplasma pneumoniae infection in children.Methods 219 cases of mycoplasma pneumonia from October 2013 to June 2015 in our hospital were divided into two groups,which were non-asthmatic group (156 cases) and wheezing group (63 cases),and the wheezing group were divided into two groups according to the presence or absence of hypoxemia and mild asthmatic group (39 cases) and severe asthmatic group (24 cases).HO-1 content in the blood was measured by enzyme-linked immunosorbent assay,using dual-wavelength spectrophotometric determination of hemoglobin oxygen percentage of broken (COHb％),analysis of the differences between the groups.Results Children with blood COHb content wheezing group were (2.59 ± 0.40)％ and HO-1 levels were (1 813.24 ± 28.34)ng/L and non-respite group were significantly increased,it had significant differences between the two groups (P＜ 0.05).Group of children with severe wheezing COHb content were (3.63 ± 0.45)％ and HO-1 levels were (2 594.34±23.94)ng/L and mild wheezing group were significantly increased,it had significant differences between the two groups (P＜0.05).Positive correlation between blood COHb content and HO-1 levels were significantly (r=0.733,P＜0.05).Conclusion Mycoplasma pneumoniae infection in children with wheezing blood COHb content and HO-1 levels were significantly increased,and with wheezing exacerbation and showed an increasing trend,suggesting that CO and HO-1 may be involved in Mycoplasma pneumoniae infection in children in the pathogenesis of wheezing,should lead to clinical attention.关键词
血红素加氧酶-1/一氧化碳/肺炎,支原体/儿童Key words
heme oxygenase-1/carbon monoxide/pneumonia, mycoplasma/child分类
医药卫生引用本文复制引用
陈小珍,王继武,何春枝..血红素加氧酶-1与一氧化碳在肺炎支原体感染患儿中的水平变化及其意义[J].重庆医学,2017,46(5):626-627,2.
