重庆医学2017，Vol.46Issue(6)：732-734,3.DOI:10.3969/j.issn.1671-8348.2017.06.004
川陈皮素对糖尿病大鼠海马Nrf-2表达及认知功能的影响
The influence of hobiletin on the cognitive impairment of diabetic rats and the expression of Nrf-2 in hippocampus
张红蕊 1赵轶群 2高晓红 1刘春梅 1李春霞 1郑佳1
作者信息
- 1. 河北省唐山市人民医院体检中心 063000
- 2. 华北理工大学研究生院,河北唐山063000
- 折叠
摘要
Abstract
Objective To explore the Hobiletin improving cognitive function and the possible mechanism to protect the hippocampal neurons.Methods Eight of Wistar rats,SPF,12 weeks of age,male,were set to the normal group;Eight of GK male rats,SPF,12 weeks of age,only for diabetes group;Both of the two groups were given the normal feed.6 of GK male rats,12 weeks of age,to feed Hobiletin of orange peel 10 mg/kg and lavage for 8 weeks,were set to the NOB group.After 22 weeks the rats were tested by Morris water maze behavior experiment for test the ability of learning and memory;the expression of Nrf-2 was detected by immunohistochemistry and Western Blot.Results Compared with the normal group,the incubation period of diabetes group was longer (P＜0.05),and theescape latency of NOB group was shorter than that of diabetes group (P＜0.05).Compared with the normal group,the residence time in the target quadrant was shorter in the diabetes group (P＜0.05),and prolonged in the NOB group than in the diabetes model group (P＜0.05).The expression of Nrf-2 in diabetes group was significantly higher than that in diabetes group (P＜0.05).The expression of NH-2 in NOB group was significantly higher than that in diabetes group (P＜0.05).Conclusion NOB can increase the expression of Nrf-2 in hippocampus and improve the cognitive function of diabetic rats,which may be related to the enhancement of Nrf-2 activity and the activation of anti-oxidative stress pathway.关键词
川陈皮素/神经元/海马/氧化应激/核因子E2相关因子2Key words
hobiletin/neurons/hippocampus/oxidative stress/Nrf-2分类
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张红蕊,赵轶群,高晓红,刘春梅,李春霞,郑佳..川陈皮素对糖尿病大鼠海马Nrf-2表达及认知功能的影响[J].重庆医学,2017,46(6):732-734,3.
