重庆医学2017，Vol.46Issue(6)：770-772,3.DOI:10.3969/j.issn.1671-8348.2017.06.016
先兆流产与MTHFR、MTRR基因多态性的关系
Investigation of the correlation of genetic polymorphism of MTHFR and MTRR and the threatened abortion
摘要
Abstract
Objective To investigate the influence of the genotype distribution of methylenetetrahydrofolate reductase (MTHFR) C677T,A1298C and methionine synthase reductase (MTRR) A66G in threatened abortion of Chinese Han gestationalage women in Sanya city,which involved in the folic acid biosynthetic pathway among.Methods One hundred and thirty-nine samples of case group and the same number of control group were recruited from Sanya region in Hainan Province.Genomic DNA was extracted from the mucosal epithelium of the subjects.The gene polyrnorphisms of MTHFR and MTRR were detected by Fluorescence quantitative PCR technology.The distribution frequencies of both case group and control group.were analyzed and compared,to investigate the effect of the gene polymorphisms on threatened abortion.Results Both the case group and the control group complied with Hardy-Weinberg law.The genotype frequency of MTHFR C677T,MTHFR A1298C and MTRR A66G were not significantly different.Conclusion This study suggests that the gene polymorphism which involved in folic metabolism was not significantly different from the group of threatened abortion and the control group,and whether the metabolism related genes are the risk factors of threatened abortion need to be further discussed.关键词
叶酸代谢障碍/流产,先兆/基因/多态性,单核苷酸/5,10-亚甲基四氢叶酸还原酶/甲硫氨酸合成酶还原酶Key words
folic acid biosynthetic pathway/abortion, threatened/gene/polymorphism, single nucleotide/5,10-methylenetetrahydrofolate reductase/methionine synthase reductas分类
医药卫生引用本文复制引用
李小兰,林琼珊,鲁衍强,李瑛,汤萍,陈春宝,杨琦..先兆流产与MTHFR、MTRR基因多态性的关系[J].重庆医学,2017,46(6):770-772,3.基金项目
中国疾病预防控制中心妇幼保健中心妇幼保健分子遗传医学研究专项计划(FY-ZX-ZD-0050) （FY-ZX-ZD-0050）
三亚市医疗卫生科技创新项目(YW1231). （YW1231）
