重庆医学2017，Vol.46Issue(7)：889-891,3.DOI:10.3969/j.issn.1671-8348.2017.07.008
NF-κB信号通路介导楤木皂甙抗宫颈癌作用及机制研究
Research on anti-cervical cancer effect of araloside mediated by NF-kappa B signaling pathway and its mechanism
摘要
Abstract
Objective To explore the inhibition role of araloside on cervical cancer HeLa cell proliferation and migration to reveal the molecular mechanism of NF-κB in HeLa cell in the process of tumor suppression.Methods The in vitro cultured cervical cancer HeLa cell line served as the research object.The experiment was divided into the control group and araloside(200 μg/mL) treatment group(observation group).The change of proliferation and migration ability after 48 h were observed in the two groups.Western blot was used to detect the expression of NF-κB molecule and change of autophagy involved protein Beclin 1 and LC3B.Results Araloside could significantly inhibit the proliferation and migration of HeLa cells and the NF-κB signaling pathway,and promoted the expression of autophagy related molecule Beclin 1,Atg 5 and LC3B.Conclusion Araloside could inhibit the NF-κB signaling pathways,thus induces autophagy occurrence and influences the proliferation and migration of cervical cancer HeLa cells.关键词
宫颈肿瘤/楤木皂苷/自噬/NF-κBKey words
uterine cervical neoplasms/araloside/autophagy/NF-kappa B分类
医药卫生引用本文复制引用
段海霞,李东红,暴蕾,李欢,高红敏..NF-κB信号通路介导楤木皂甙抗宫颈癌作用及机制研究[J].重庆医学,2017,46(7):889-891,3.基金项目
陕西省科学技术研究发展计划基金资助项目(2013K12-03-22). （2013K12-03-22）
