重庆医学2017，Vol.46Issue(7)：892-895,4.DOI:10.3969/j.issn.1671-8348.2017.07.009
冠心病患者血管重建后吸烟状态对临床预后的影响
Effect of smoking on clinical prognosis after vascular reconstruction in patients with coronary heart disease
摘要
Abstract
Objective To investigate the effect of smoking status after vascular construction on the long term prognosis in the patients with coronary heart disease(CHD).Methods Totally 893 patients with CHD were divided into 3 groups according to the smoking status before and after vascular construction,non-smoking group(n=458),quiting smoking group(n=287) and smoking group(n=148).The occurrence situation of major adverse cardiovascular and cerebrovascular events(MACCE) during follow-up period were recorded in detail.The postoperative cumulative survival rate was described by using Kaplan-Meier survival analysis.The effect of smoking status on the all-cause death and MACCE was compared.The Cox stepwise regression analysis was used to analyze the all-cause death and the influence factors of MACCE.Results The average follow up time was about 27 months,the postoperative smoking rate was significantly lower than the preoperative multivariable smoking rate(16.57 ％ vs.48.71％),the patients in the smoking group were younger (P＜0.01);the patients in the non-smoking group were mainly female (P＜0.01),the body mass index (BMI) was smaller(P＜0.01).The all-cause death in the smoking group was higher (1.53％ vs.1.05％ vs.6.76％,P=0.002) and the occurrence rate of MACCE was higher (4.37％ vs.5.23％ vs.15.54％,P=0.001).The Cox multivariable stepwise regression analysis showed that postoperative persistent smoking was an important risk factor leading to the all-cause death[HR=2.753,95％CI(1.695-4.473),P＜0.01] and MACCE[HR=1.552,95％CI(1.049-1.754),P=0.001].Conclusion Persistent smoking is an independent risk factor leading to all-cause death and MACCE occurrence in CHD patients after vascular construction.关键词
冠心病/血管重建/吸烟/预后Key words
coronary disease/revascularization/smoking/prognosis分类
医药卫生引用本文复制引用
郭素萍,刘军,高传玉,肖文涛,张静,寇洁..冠心病患者血管重建后吸烟状态对临床预后的影响[J].重庆医学,2017,46(7):892-895,4.基金项目
河南省科技厅重点攻关项目(142102310396). （142102310396）
