大连工业大学学报2017，Vol.36Issue(1)：1-5,5.
一种新型海洋多糖组方对环磷酰胺致免疫低下小鼠免疫功能的影响
Effect of a new type of marine polysaccharides on immune function of mice induced with cyclophosphamide
摘要
Abstract
The effect of a new type of marine polysaccharide on immunosuppressive model in mice was studied.The immunosuppressive mice induced with cyclophosphamide were selected as the animal model,and the correction clearance index,toe thickness,weight growth rate,thymus index,spleen index,half hemolysis value and NK cell activity were tested after 35 d when high,middle and low-dose (1.5,0.5 and 0.25 g/kg) of the marine polysaccharide were given by gavage once a day,respectively.Compared with the control group,correction clearance index,toe thickness differences,half hemolysis value and NK cell activity of the high and middle doses groups improved significantly.The body weight growth rates of each group showed no significant differences.The thymus index and spleen index of the high dose group of the polysaccharide increased significantly.The results indicated that the new type of marine polysaccharide could significantly improve the immunology functions of the immunosuppressive mice.关键词
海洋多糖/免疫调节/环磷酰胺Key words
marine polysaccharides/immunomodulation/cyclophosphamide分类
轻工纺织引用本文复制引用
妥丰艳,于建伟,启航,王桐,辛丘岩,周大勇..一种新型海洋多糖组方对环磷酰胺致免疫低下小鼠免疫功能的影响[J].大连工业大学学报,2017,36(1):1-5,5.基金项目
国家高技术研究发展计划(863计划)项目(2014AA093602) （863计划）
国家海洋公益性行业科研专项经费项目(201505029) （201505029）
大连市高层次人才创新支持计划项目(2016RQ063). （2016RQ063）
