动物医学进展2017，Vol.38Issue(1)：61-64,4.
抗脂肪细胞膜蛋白抗体对试验性肥胖大鼠5种激素水平的影响
Effects of Antibody against Adipocyte Membrane Protein on Five Kind of Hormone Levels in Experimental Obese Rats
摘要
Abstract
To verify the effects of antibody against adipocyte membrane protein on animal fat deposition and provide the theoretical basis and experimental data for using the antibody to reduce human obesity,sixty experimental obese rats were injected with antibodies at 0,0.1,0.5,1.0 mg/mL respectively and the serum hormone contents were determinated every week.The results showed that the INS content in treatment groups was lower than that in the control group,but there was significant difference between Ⅰ group and Ⅳ groups(P<0.05).The content of IGF-1 showed no significant difference between treatment groups and control group (P>0.05).The GH contents in treatment groups increased significantly compared with the control group,and there was significant difference between Ⅰ group and Ⅲ group at 4 week (P<0.05).In the first week,the contents of T3 in treatment groups had no significant difference with control group(P>0.05).But it showed significant difference between Ⅰand Ⅳ groups during the next 3 weeks(P<0.05).The T4 contents in Ⅰand Ⅳ groups had significant difference at 1st,3rd and 4th week(P<0.05),and the Ⅱ group and Ⅲ group had similar tendency at 4 weeks(P>0.05).In conclusion,the hormones among different groups varied with the dose of antibody injected.关键词
抗脂肪细胞膜蛋白抗体/试验性肥胖大鼠/激素Key words
antibody against adipocyte membrane protein/experimental obese rat/hormone分类
农业科技引用本文复制引用
刘超英,胡忠梅,李卫真,张永云,赵素梅,代飞燕,彭洁,俞大阔,和绍禹..抗脂肪细胞膜蛋白抗体对试验性肥胖大鼠5种激素水平的影响[J].动物医学进展,2017,38(1):61-64,4.基金项目
国家自然科学基金项目 (30260079) （30260079）
