动物医学进展2017，Vol.38Issue(2)：75-78,4.
牛传染性鼻气管炎病毒致病机制研究进展
Progress on Pathogenetic Mechanism of Infectious Bovine Rhinotracheitis Virus
摘要
Abstract
Infectious bovine rhinotracheitis (IBR) is caused by infectious bovine rhinotracheitis virus (IBRV) with the characteristic of severe inflammation,expiratory dyspnea and abortion in bovine,and is pandemic around the world and causing enormous economic losses.However,there is no available research for the pathogenetic mechanism of IBRV.Yet viral structural or non-structural proteins are associated with its virulence that have effect on IBRV replication,infection and immune escape.Moreover, IBRV can induce apoptosis on host cells, and can result in serious inflammatory response by activation of inflammasome, which can lead to persistent infection of IBRV and extensive pathophysiological process.Therefore, the exploration of structure and function of IBRV virulent protein(s), the mechanism of apoptosis induction and activation of inflammasome on infected host cells would be the focus on in the IBRV research area in the future.关键词
牛传染性鼻气管炎病毒/毒力蛋白/细胞凋亡/炎症复合体Key words
Infectious bovine rhinotracheitis virus/virulent protein/apoptosis/inflammasome分类
农业科技引用本文复制引用
许健,沈俊俊,黄秀芬,李永清..牛传染性鼻气管炎病毒致病机制研究进展[J].动物医学进展,2017,38(2):75-78,4.基金项目
现代农业技术体系北京市奶牛创新团队岗位专家自助经费项目(bjcystx-ny-3) （bjcystx-ny-3）
