南方医科大学学报2016，Vol.36Issue(12)：1616-1620,5.DOI:10.3969/j.issn.1673-4254.2016.12.05
早期不同的血压控制目标对高血压性脑出血患者血肿扩大及预后的影响
Effect of different blood pressure control targets within 48 h after hypertensive cerebral hemorrhage on hematoma enlargement and prognosis
摘要
Abstract
Objective To study the effect of different blood pressure control targets on hematoma enlargement and prognosis in patients within 48 h after hypertensive cerebral hemorrhage (HCH).Methods Between January,2013 and July,2016,102 patients with HCH were randomized into group A (51 cases) and group B (51 cases) with different systolic blood pressure (SBP) control targets within 48 h.The patients in group A were given early active antihypertensive treatment with SBP control target of 130-140 mm Hg;those in group B received standard antihypertensive treatment with SBP control target of 170-180 mm Hg.The changes in the volume of hematomas and the patients' prognosis were compared between the two groups.Results After 48 h of treatment,SBP,hematoma volume and the National Institutes of Health Stroke Scale (NIHSS) score were significantly lower and Glasgou Coma Scale (GCS) score was significantly higher in group A than in group B (P＜0.01 or 0.05).After 30 days of treatment,the patients in group A showed significantly better indicators of treatment efficacy than those in group B (Z=2.331,P=0.020).The mortality rate was lower in group A than in group B,but the difference was not statistically significant (x2=2.772,P=0.096).Condusion Early active antihypertensive treatment is safe and feasible in patients with HCH and can reduce the enlargement of the hematomas,alleviate deterioration of neurological function,and improve the prognosis of the patients.关键词
血压,控制目标/高血压性脑出血/血肿扩大/预后Key words
blood pressure/control target/hypertensive cerebral hemorrhage/hematoma enlargement/prognosis引用本文复制引用
张洪涛,禹萌,任雅芳,张斌,张淑玲,付胜奇,张道培..早期不同的血压控制目标对高血压性脑出血患者血肿扩大及预后的影响[J].南方医科大学学报,2016,36(12):1616-1620,5.基金项目
国家重点基础研究发展计划(973计划)(2012CB517800)Supported by National Key Basic Research Program (2012CB517800). （973计划）
