南方医科大学学报2016，Vol.36Issue(12)：1718-1722,5.DOI:10.3969/j.issn.1673-4254.2016.12.22
环氧合酶-2和碱性成纤维细胞生长因子在鼻咽癌组织中的表达及与放疗敏感性的相关性
Expressions of cyclooxygenase-2 and basic fibroblast growth factor in nasopharyngeal carcinoma and their association with radiotherapy sensitivity
摘要
Abstract
Objective To detect the expressions of cyclooxygenase-2 (COX-2) and basic fibroblast growth factor (bFGF) and evaluate their value in predicting the radiotherapy sensitivity in nasopharyngeal carcinoma (NPC).Methods The expressions of COX-2 and bFGF were detected immunohistochemically in biopsy samples of NPC,and their relationship with the radiotherapy sensitivity of the tumors were analyzed.Results In 97 NPC cases,the positivity rates of COX-2 and bFGF were 71.1％ (69/97) and 64.9％ (63/97),respectively.Correlation analysis demonstrated that a positive COX-2 expression was positively correlated with an advanced T status and N status,and bFGF expression was positively associated with an advanced N status in NPCs.In radiotherapy-sensitive and radiotherapy-insensitive cases,the positive rate of COX-2 was 62.8％ and 92.6％,and that of bFGF was 57.1％ and 85.2％,respectively.The expression of COX-2 was positively correlated with that of bFGF (r=0.486,P＜0.05).The radiotherapy sensitivity differed significantly among patients with different statuses of COX-2 and bFGF positivity.Conclusion COX-2 and bFGF can be effective and sensitive biomarkers for predicting radiotherapy sensitivity关键词
鼻咽癌/环氧合酶-2/碱性成纤维细胞生长因子/放疗敏感性Key words
nasopharyngeal carcinoma/COX-2/basic fibroblast growth factor/radiotherapy sensitivity引用本文复制引用
赵建夫,徐萌,陈文慧,赵凤芝,王奕鸣,庄承海..环氧合酶-2和碱性成纤维细胞生长因子在鼻咽癌组织中的表达及与放疗敏感性的相关性[J].南方医科大学学报,2016,36(12):1718-1722,5.基金项目
国家自然科学基金(81273814) （81273814）
广东省重大新药创制重大科技专项(2013A022100031)Supported by National Natural Science Foundation of China (81273814). （2013A022100031）
