南方医科大学学报2017，Vol.37Issue(2)：157-164,8.DOI:10.3969/j.issn.1673-4254.2017.02.03
子宫内膜癌中MAP2K4和波形蛋白的表达及临床意义
Coexpression of MAP2K4 and vimentin proteins in human endometrial carcinoma and its clinicopathological significance
摘要
Abstract
Objective To analyze the expression of MAP2K4 and vimentin in human endometrial carcinoma (EC) and their association with the clinicopathological features and prognosis of the patients.Methods MAP2K4 and vimentin expressions were detected immunohistochemically in paraffin-embedded tissue sections from 128 patients with EC,and the correlation of MAP2K4 and vimentin expressions with the dinicopathological factors of the patients was analyzed.Results MAP2K4 and vimentin proteins were positively expressed in 49 (38.3％) and 83 (64.8％) of the patients,respectively.A positive expression of MAP2K4 was negatively correlated with FIGO stage of the tumor (P=0.010) and lymph node status (P=0.016);a positive expression of vimentin was positively correlated with FIGO stage of the tumor (P=0.025),histological grades (P=0.017),depth of myometrial invasion (P=0.044) and lymph node status (P=0.032).MAP2K4 was inversely associated with vimentin expression in EC(r=0.598,P＜0.001).Patients positive for MAP2K4 tended to have a higher overall survival rate (P=0.002),and those positive for vimentin tended to have a lower overall survival rate (P=0.007);patients positive for MAP2K4 but negative for vimentin had the longest survival time,while those negative for MAP2K4 and positive for vimentin had lowest survival rate (P=0.004).Conclusion Detection of MAP2K4 and vimentin might help in early diagnosis and prognostic evaluation of patients with EC.关键词
子宫内膜癌/丝裂原活化蛋白激酶4/波形蛋白/免疫组化Key words
endometrial carcinoma/MAP2K4/vimentin/immunohistochemistry引用本文复制引用
刘春花,江庆萍,林丹,陈炜,肖艳怡,林莉,邓渊润,蒋惠萍,郭遂群..子宫内膜癌中MAP2K4和波形蛋白的表达及临床意义[J].南方医科大学学报,2017,37(2):157-164,8.基金项目
广东省科技计划项目(2016ZC0087) （2016ZC0087）
