南方医科大学学报2017，Vol.37Issue(2)：165-171,7.DOI:10.3969/j.issn.1673-4254.2017.02.04
光学相干断层扫描诊断息肉状脉络膜血管病变的敏感性和特异性
Sensitivity and specificity of optical coherence tomography in diagnosing polypoidal choroidal vasculopathy
摘要
Abstract
Objective To establish the diagnostic criteria for polypoidal choroidal vasculopathy (PCV) based on spectral-domain optical coherence tomography (SD OCT) by evaluating the sensitivity and specificity of SD OCT in differentiating PCV from wet age-related macular degeneration (wAMD).Methods The clinical data were reviewed for 62 patients (63 eyes) with the initial diagnosis of PCV or wAMD between August,2012 and June,2016.Twenty-four patients (25 eyes) were diagnosed to have PCV and 38 (38 eyes) had wAMD based on findings by fundus photography,fluorescein angiography (FFA) and indocyanine green angiography (ICGA).Among the 6 features of SD OCT,namely a sharp RPED peak,double-layer sign,multiple RPED,an RPED notch,a hyporeflecfive lumen representing polyps,and hyperreflecfive intraretinal hard exudates,findings of the first two features and at least one of the other features sufficed the diagnosis of PCV;in the absence of the first two features,the diagnosis of PCV was also made when at least 3 of the other features were present simultaneously.The sensitivity and specificity of SD OCT-based diagnosis were estimated by comparison with the gold standard ICGA-based diagnosis.Results In the 25 eyes with an established diagnosis of PCV,23 eyes (92.0％) met the diagnostic criteria based on SD OCT findings;in the 38 eyes with the diagnosis of wAMD,only 4 eyes (10.5％) met the criteria.The sensitivity and specificity of SD OCT-based diagnosis of PCV was 92.0％ and 89.5％,respectively.Conclusions We established the diagnostic criteria for PCV based on SD OCT findings with a high sensitivity and specificity.SD OCT shows a strong capacity for differentiating PCV from wAMD.关键词
光学相干断层扫描/息肉状脉络膜血管病变/年龄相关性黄斑变性/诊断Key words
optical coherence tomography/polypoidal choroidal vasculopathy/age-related macular degeneration/diagnosis引用本文复制引用
张怡,姚静,王肖华,赵琳,王丽君,王建明,周爱意..光学相干断层扫描诊断息肉状脉络膜血管病变的敏感性和特异性[J].南方医科大学学报,2017,37(2):165-171,7.基金项目
陕西省科技攻关项目(2012K19-05-05) （2012K19-05-05）
