中国耳鼻咽喉头颈外科2017，Vol.24Issue(3)：124-127,4.DOI:10.16066/j.1672-7002.2017.03.004
手术干预对阻塞性睡眠呼吸暂停低通气综合征儿童外周T淋巴细胞亚群及NK细胞活性的影响
Effect of surgical intervention on the activity of peripheral blood T lymphocyte subsets and NK cell in children with obstructive sleep apnea hypopnea syndrome
摘要
Abstract
OBJECTIVE To explore the condition of the cellular immune function of children with obstructive sleep apnea hypopnea syndrome(OSAHS) and its change after operation METHODS Eighty children diagnosed as OSAHS were included in this study. T lymphocyte subsets and NK cells of the blood were measured before operation and one month after operation respectively. Children without the related disorders or systemic disease were recruited as control group.RESULTS Before operation, CD4+T cell percentage, CD4+/CD8+ ratio and NK cell percentage in OSAHS children were significantly lower than that in the control group[(26.19±3.38)%vs (5.10±4.09)%, (0.90±0.19)%vs (1.61±0.52)%, (11.45±4.35)%vs (13.73±3.78)%,P<0.05], CD8+T cell percentage was significantly higher than that in the control group[(30.02±5.50)%vs (22.31±3.42) %,P<0.05]. The difference, between the two groups, in CD3+T cells was not statistically significant. After operation, the CD4+T cells, CD8+T cells, CD4+/CD8+ ratio, the percentage of NK cells and CD3+T cells showed no significance difference compared with that before operation (P>0.05). CONCLUSION OSAHS may damage the cellular immune function. The operation does not reduce the cellular immune function in the short term.关键词
睡眠呼吸暂停,阻塞性/儿童/扁桃体切除术/腺样体切除术/免疫,细胞Key words
Sleep Apnea/Obstructive/Child/Tonsillectomy/Adenoidectomy/Immunity/Cellular引用本文复制引用
陈翊民,黄莉莉,王佳蓉,邱连升..手术干预对阻塞性睡眠呼吸暂停低通气综合征儿童外周T淋巴细胞亚群及NK细胞活性的影响[J].中国耳鼻咽喉头颈外科,2017,24(3):124-127,4.基金项目
福建省泉州市科技局项目(2015Z62) （2015Z62）
