中国耳鼻咽喉头颈外科2017，Vol.24Issue(3)：153-155,3.DOI:10.16066/j.1672-7002.2017.03.011
水杨酸钠作用后大鼠伏隔核内多巴胺水平变化
Effects of salicylate on dopamine levels in rat nucleus accumbens
摘要
Abstract
OBJECTIVE To investigate dopamine level changes in the Nucleus Accumbens (NAc) of the limbic system by salicylate and the role of dopamine in the mechanisms of tinnitus.METHODS We recorded the change of dopamine before and after sodium salicylate injection in rats by microdialysis combined with electrochemical methodologies in the nucleus accumbens (NAc).RESULTS Salicylate produced significant increase in dopamine level in the NAc, to a maximum of (321±97)% of baseline and then remain stable. In contrast, saline only produced slight increase.CONCLUSION The increase of dopamine in the NAc may be related to the generation of tinnitus. The data in vivo provide direct evidence of the important role that the dopaminergic system plays in the generation of tinnitus.关键词
动物实验/水杨酸钠/大鼠/耳鸣/多巴胺/伏隔核/微透析Key words
Animal Experimentation/Sodium Salicylate/Rats/Tinnitus/Dopamine/nucleus accumbens/microdialysis引用本文复制引用
胡伟倪,刘俊秀,毛兰群,马芙蓉..水杨酸钠作用后大鼠伏隔核内多巴胺水平变化[J].中国耳鼻咽喉头颈外科,2017,24(3):153-155,3.基金项目
国家自然科学基金资助项目(21272018和21372020) （21272018和21372020）
