儿科药学杂志2017，Vol.23Issue(3)：15-18,4.DOI:10.13407/j.cnki.jpp.1672-108X.2017.03.005
硫酸镁早期干预治疗重症手足口病临床观察及对儿茶酚胺水平的影响
Early Intervention for the Treatment of Severe Hand, Foot and Mouth Disease with Magnesium Sulfate and Its Effects on Blood Level of Catecholamine
摘要
Abstract
Objective:To observe the changes of catecholamine and effect of magnesium sulfate for the treatment of severe hand,foot and mouth disease (HFMD) children with the nervous system involvement (NSI),provide a theoretical basis for early effective intervention therapy to catecholamine of severe HFMD children.Methods:Eighty-two cases of children who were diagnosed as severe HFMD and blood glucose ≥7.8 mmol/L were selected in this study.All the children were randomly divided into treatment group and control group,all cases received routine treatment based on their symptoms,intravenous infusion of 25％ magnesium sulfate 50 to 60 mg/(kg · d) was given in the treatment group.Venous blood was sampled before and 72 h after intravenous infusion magnesium sulfate for measurements of white blood cell (WBC),blood glucose (BG),creatine kinase isoenzyme (CK-MB),neuron-specific enolase (NSE).Meanwhile,the levels of plasma norepinephrine (NE),adrenaline (E) and dopamine (DA) were measured.Continuously observed and recorded the duration of neurological involvement and hospitalization time of children in two groups.The curative effect between the two groups was compared.Results:All cases of the two groups of severe HFMD fully recovered and discharged:(1) The levels of DA,NSE,BG,WBC,CK-MB were decreased in treatment group,and only the level of NSE decreased in control group,what' s more the levels of NE,DA,NSE in treatment group were lower than those in control group (all P ＜ 0.05).Duration of neurological involvement in the treatment group was shorter than that of control group (P＜0.05).Conclusion:Early magnesium sulfate treatment can attenuate acute excessive release of catecholamine as well as the side effects of hormones,and can provide protective effects on myocardial and cerebral lesion induced by virus invasion.This may be helpful to effectively prevent severe HFMD children with NSI from further deterioration.关键词
手足口病/儿茶酚胺/硫酸镁/神经系统受累期Key words
hand, foot and mouth disease/catecholamine/magnesium sulfate/nervous system involvement分类
医药卫生引用本文复制引用
刘绍华,张志,邱燕玲,李湘玲,刁诗光,肖小兵,邱建武,谢国粦,曾雅丽,黄冬梅..硫酸镁早期干预治疗重症手足口病临床观察及对儿茶酚胺水平的影响[J].儿科药学杂志,2017,23(3):15-18,4.基金项目
广东省医学科学技术研究基金项目,编号A2013717 （）
韶关市卫生局立项课题,编号Y13143. （）
