广东医学2017，Vol.38Issue(1)：24-28,5.
短程放疗联合替莫唑胺在老年胶质母细胞瘤患者中的生存获益分析
An prognostic analysis of hypofractionated radiation plus Temozolomide for newly diagnosed glioblastoma in eld-erlies
摘要
Abstract
Objective To investigate if a short -course concurrent chemoradiotherapy that yields a better mean survival in elderly patients with newly diagnosed glioblastoma multiforme (GBM) and poor post -operation performance. Methods This study included 71 newly diagnosed primary GBM patients aged 65 years or older with poor post -opera-tion KPS.Kaplan-Meier method stratified by MGMT status was used to compared the survival in different groups .Re-sults The mean age was (71.10 ±5.19) years old, among whom the mean age of 50 males was (71.36 ±5.35)years, and of 21 females was (70.48 ±4.90) years.Sixty-two cases died during follow -up, and the two-year survival rate was 0%.The mean overall survival of short -course concurrent chemoradiotherapy increased significantly ( P=0.002 ) compared to short-course radiotherapy -alone and TMZ-alone ( P=0.001 ) .It got more survival benefit for patients with negative MGMT (P=0.004).But there was no significant difference between short -course radiotherapy -alone and TMZ-alone (P>0.05).Conclusion Short-course concurrent chemotherapy may be a optimization adjuvant therapy plan to elderly patients with newly diagnosed GBM and poor post -operation performance , and this advantage is more obvi-ous in patients with MGMT promotor methylation .关键词
老年/辅助治疗/胶质母细胞瘤/预后Key words
elderly patients/adjuvant therapy/glioblastoma/prognosis引用本文复制引用
陈子阳,欧阳辉,陆云涛,袁亚维,俞磊,刘亚伟,漆松涛..短程放疗联合替莫唑胺在老年胶质母细胞瘤患者中的生存获益分析[J].广东医学,2017,38(1):24-28,5.基金项目
国家自然科学基金资助项目(编号:81372692),国家重点专科建设项目 （编号:81372692）
