广东医学2017，Vol.38Issue(3)：345-348,4.
IRE-1信号通路在野百合碱诱导大鼠肺动脉高压中的作用
The mechanism study of the IRE-1 signal pathway in the development of pulmonary arterial hypertension in rats
摘要
Abstract
Objective To investigate the effects of IRE -1 signal pathway in the development of pulmonary arte-rial hypertension (PAH) in rats.Methods Wistar rats were randomly divided into normal control group , PAH model group, and treatment group .The PAH model in rats was established by the method of bolus intraperitoneal injection of monocrotaline.And 4 -phenylbutyric acid (4-PBA) was continuously administrated two weeks after modeling in the treatment group .The parameters of hemodynamics , pathology and the quantitative results of mRNA expression in IRE -signaling pathway were tested in 3 groups.Results After the intervention of 4-PBA, the mean pulmonary artery pres-sure ( mPAP) , average right ventricular pressure ( mRVP) , and the pulmonary vascular remodeling indicators were signif-icant reduced in treatment group compare with the PAH model group (P<0.01).Furthermore, the mRNA expression of the key factors of IRE-1 signaling pathway , GRP78 and Ire-1α, were significant reduced in treatment group compare with the PAH model group (P<0.01).Conclusion Endoplasmic reticulum (ER) stress induced by IRE -1 signaling pathway plays a significant role in the occurrence and development of pulmonary hypertension .Additionally , we show that the inhibition of IRE-1 signal pathway in ER stress has the potential influence on reducing pulmonary artery pressure and lung small artery remodeling .关键词
肺动脉高压/内质网应激/4-苯基丁酸/IRE-1信号通路Key words
pulmonary arterial hypertension/endoplasmic reticulum stress/4-phenylbutyric acid/IRE-1 sig-nal pathway引用本文复制引用
王捷,龙梅,李倩,阿里旦·艾尔肯,武云..IRE-1信号通路在野百合碱诱导大鼠肺动脉高压中的作用[J].广东医学,2017,38(3):345-348,4.基金项目
新疆维吾尔自治区自然科学基金青年科学基金项目 (编号:2014211C071) （编号:2014211C071）
