广东医学2017，Vol.38Issue(3)：374-377,4.
脂蛋白磷脂酶A2和髓过氧化物酶与超敏C反应蛋白及全球急性冠状动脉事件注册评分的相关性
Correlations among lipoprotein-associated phospholipase A2, myeloperoxidase, C-reactive protein and global registry of acute coronary events risk score in patients with coronary heart disease
摘要
Abstract
Objective To investigate the correlations among Lp -PLA2, MPO, C-reactive protein (Hs-CRP) and global registry of acute coronary events risk score ( GRACE) risk score in patients with CHD .Methods A hundred and fifty patients were divided into 3 groups undergoing the coronary angiography , stable myocardial infarction ( SMI ) group (n=28), stable angina pectoris (SAP) group (n=59), and ACS group (n=63).The serum levels of Lp -PLA2 and MPO were detected by enzyme -linked immunosorbent assay (ELISA), the serum level of Hs-CRP was detected by latex immunoturbidimetry , and GRACE risk scores were recorded .The correlations among Lp -PLA2, MPO, Hs-CRP and GRACE risk score were analyzed .Results The serum levels of Lp -PLA2, MPO and Hs-CRP in ACS group were significantly higher than SAP group and SMI group (P<0.05), while there was no significant difference in serum Lp -PLA2, MPO or Hs-CRP between SAP group and SMI group (P>0.05).Lp-PLA2 was significantly correlated with MPO and Hs-CRP in CHD groups (r=0.793, P<0.05; r=0.769, P<0.05); meanwhile, MPO was significantly correlated with Hs-CRP in CHD groups ( r=0.743, P<0.05).There was no significant correlation between Lp -PLA2, MPO or Hs-CRP and GRACE risk score in CHD groups .Conclusion It can further help to assessment the strat-ification of CHD risk and can be more beneficial to predicting and treating the coronary artery disease by jointing test the serum levels of Lp-PLA2, MPO and Hs-CRP or using GRACE risk scores.关键词
冠心病/脂蛋白磷脂酶A2/髓过氧化物酶/超敏C反应蛋白/全球急性冠状动脉事件注册评分Key words
coronary heart disease/lipoprotein -associated phospholipase A 2/myeloperoxidase/C-reactive protein/global registry of acute coronary events risk score引用本文复制引用
李琳,李芳,肖婷,李妍,曾欧,吴洁,刘厂辉,杨军,褚春..脂蛋白磷脂酶A2和髓过氧化物酶与超敏C反应蛋白及全球急性冠状动脉事件注册评分的相关性[J].广东医学,2017,38(3):374-377,4.基金项目
国家自然科学基金资助项目(编号:81270181,81202830) （编号:81270181,81202830）
