摘要
Abstract
Objective To explore the effect of iguratimod on the Th1 / Th17 ratio in T lymphocyte subsets and the expression level of RORc in patients with rheumatoid arthritis (RA).Methods Sixty-four patients with RA admitted into the department of rheumatology and the department of orthopaedics at our hospital from June,2014 to June,2016 were divided into an observation group and a control group according to the admission order,32 cases for each group.After being given calcium supplement,pain relief,gastric mucosal protection,and other basic symptomatic treatment,the control group orally took iguratimod placebo and the observation group iguratimod.The changes of Th 1/Th 17 ratio in T lymphocyte subsets and the expression level of RORc before and after treatment were observed and compared between the two groups.And the incidences of adverse reactions were also compared.Results The levels of Th1 and Th17 and Th1/Th17 were significantly lower after than before the treatment (t=6.420,3.428,7.985) and were in observation group than in control group after the treatment (t=3.596,4.847,2.376) (P ＜ 0.05).The proportion of regulatory T cells was significantly higher in the observation group than in the control group after the treatment (t=3.159).The levels of RORc and T-bet (t=-9.454,3.128 and 5.025,2.848) were significantly lower and the expression level of Foxp3 (t=-5.129 and 3.925)was significantly higher after than before the treatment in both group and there were statistical differences between these two group (P ＜ 0.05).There was no statistical difference in the incidence of adverse reactions between these two groups (x2=0.217,P ＞ 0.05).Conclusions Through the down-regulation of the expression level of Th cell related transcription factor RORc mRNA,iguratimod can reduce the proportions of Thl and Th7 and Thl/Th7 in Th cell subsets,increase the proportion of regulatory T cells,alleviate T cell mediated inflammatory reactions,and relieve the patients' clinical symptoms.关键词
艾拉莫德/类风湿关节炎/T淋巴细胞亚群/疗效Key words
Iguratimod/Rheumatoid arthritis/T lymphocyte subsets/Curative effect
