摘要
Abstract
Objective To observe effect of erythromycin on motilin,gastrin,and intestinal flora in diabetic patients with gastroparesis.Methods 78 DGP outpatients and inpatients treated at the department of gastroenterology of our hospital from September,2011 to September,2013 were randomly divided into an observation group and a control group.The control group were treated with mosapride tablets and the observation group erythromycin capsules.The efficacy,the levels of plasma motilin (MLT) and serum gastrin (GAS),and the numbers of intestinal flora were compared between these two groups.Results After the treatment,the total effective rate was significantly higher in the observation group than in the control group(x 2=12.889,P ＜ 0.05);the levels of plasma motilin and serum gastrin significantly decreased in both groups (P ＜ 0.05) and were significantly lower in the observation group than in the control group (t=-13.865 and 6.272,P ＜ 0.05);there were no statistical differences in the numbers of escherichia coli,bacillus,lactobacillus,lactic acid bacteria in the intestine between the two groups before and after the treatment (t=1.540,1.093,1.790,and 1.946,P ＞ 0.05);the number of bacteroid was significantly more in the observation group than in the control group (t=8.073,P ＜ 0.05).Conclusions Erythromycin in the treatment of diabetic gastroparesis is remarkably effective,can reduce motilin,gastrin secretion,and has little influence on intestinal flora of patients and better applied value,so it is worth being clinically used.关键词
糖尿病胃轻瘫/红霉素/胃动素/胃泌素/肠道菌群Key words
Diabetes with gastroparesis/Erythromycin/Motilin/Gastrin/Intestinal flora
