摘要
Abstract
Objective To explore the prevention and treatment effect of pulmonary surfactant and noninvasive SNIPPV in persistent pulmonary hypertension of late preterm infants (LPI).Methods A retrospective analysis was carried out on 126 cases of LPI with neonatal respiratory distress syndrome (NRDS) or meconium aspiration syndrome (MAS) admitted to neonatology department of our hospital from January 2010 to January 2016,who were divided into treatment group (70 cases) and control group (56 cases) according to whether the use of pulmonary surfactant and noninvasive SNIPPV model.The rates of PPHN,mechanical ventilation,mechanical ventilation once more after the extubation,the average mechanical ventilation time,high PIP time,and high FiO2 time in the two groups were compared.Results The rates of PPHN,mechanical ventilation,mechanical ventilation once more after the extubation in the treatment group were all lower than those in the control group (17.14％ vs.41.07％,25.71％ vs.85.71％,4.29％ vs.25.00％),with statistically significant differences (P＜0.05).The average mechanical ventilation time,high PIP time,and high FiO2 time in the treatment group were all shorter than those in the control group,with statistically significant differences (P＜0.05).Conclusions The early use of pulmonary surfactant and SNIPPV in the treatment of late preterm infants with NRDS or MAS,can help to reduce the occurrence of PPHN,reduce the rates of mechanical ventilation,mechanical ventilation once more after the extubation,shorten hospitalization time,reduce the mortality,is conducive to improve the prognosis of high-risk LPI.关键词
持续肺动脉高压/早产儿/晚期/肺表面活性物质/SNIPPV/机械通气Key words
Persistent pulmonary hypertension/Premature/Late/Pulmonary surfactant/SNIPPV/Mechanical ventilation
