广东药学院学报2017，Vol.33Issue(1)：72-76,5.DOI:10.16809/j.cnki.2096-3653.2016101703
钩藤总生物碱对慢性束缚应激小鼠的抗抑郁作用
Antidepressant effect of total alkaloids from Uncaria in chronic restraint stress mice
摘要
Abstract
Objective To study the antidepressant effect of total alkaloids from Uncaria ( TAU) in chronic restraint stress ( CRS) mice. Methods Mice were restrained for 8 h daily in a special centrifuge tube for 10 consecutive days to establish the model of depressive mice. The model mice were intragastrically administrated 80, 40 and 20 mg/kg TAU and 10 mg/kg fluoxetine. The behavioral changes were observed by spontaneous activity test, forced swim test and sucrose preference test to evaluate antidepressant effect of TAU. ELISA was used to detect the levels of serum corticosterone ( CORT) , TNF-αand NO. Results TAU significantly increased body weight, shortened immobility period and enhanced sucrose preference in CRS mice. Furthermore, TAU decreased the contents of serum CORT, TNF-αand NO. Conclusion TAU exhibits an antidepressant activity in CRS mice, possibly through regulation of hypothalamus-pituitary-adrenal ( HPA) axis.关键词
钩藤总生物碱/抑郁症/慢性束缚应激/皮质酮/TNF-α/NOKey words
total alkaloids from Uncaria/depression/chronic restraint stress/corticosterone/TNF-α/NO分类
中医学引用本文复制引用
刘松林,徐玉秀,黄燕俊,曾常青..钩藤总生物碱对慢性束缚应激小鼠的抗抑郁作用[J].广东药学院学报,2017,33(1):72-76,5.基金项目
贵州省剑河县中药材产业科技合作专项计划项目[剑科合字(2014)4号] （2014）
