国际口腔医学杂志2017，Vol.44Issue(2)：204-208,5.DOI:10.7518/gjkq.2017.02.018
牙周韧带细胞膜片技术用于牙周组织再生的研究进展
Advances in periodontal regeneration with periodontal ligament cell sheet technique
姜雨汐 1刘树泰2
作者信息
- 1. 滨州医学院口腔医学院 烟台264000
- 2. 烟台市口腔医院牙周科 烟台264000
- 折叠
摘要
Abstract
Achieving complete periodontal tissue regeneration that arises from periodontitis show some difficulties.The principles of guided tissue regeneration indicate that cell sheet engineering aims to achieve the regeneration of periodontal ligament embedded in new cementum and new alveolar bone by several novel cell-transferring methods.For example,UpCell culture dish can control cell-surface adhesion and utilize temperature change in cell culture and a surface-grafted temperature-sensitive polymer named poly N-isopropylacylamide.Cell sheets have been harvested from temperaturesensitive culture surfaces non-invasively and overlaid as multilayered constructs.Cell sheet technique has improved in recent years and has overcome many obstacles,such as the inadequate thickness of monolayer cell sheet,the insufficient vascularization,and the lack of autologous cell sources.Owing to the high metabolic turnover rates of the periodontal ligament,many researchers have considered periodontal ligament cells as one of the most suitable candidate cell sources for regeneration.A clinical study of periodontal regeneration with autologous periodontal ligament cell sheet has been recently performed on humans in Japan.This article reviews the recent advances of techniques in periodontal ligament cell sheet engineering and its application in periodontal regeneration.关键词
细胞膜片技术/牙周韧带细胞/UpCell培养皿/去细胞化/牙周组织再生Key words
cell sheet technique/periodontal ligament cell/UpCell culture dish/decellularization/periodontal regeneration分类
生物科学引用本文复制引用
姜雨汐,刘树泰..牙周韧带细胞膜片技术用于牙周组织再生的研究进展[J].国际口腔医学杂志,2017,44(2):204-208,5.
