国际神经病学神经外科学杂志2017，Vol.44Issue(1)：1-4,4.DOI:10.16636/j.cnki.jinn.2017.01.001
CYP17A1和AR在脑胶质瘤中的表达及意义
Expression of CYP17A1 and androgen receptor in glioma and its clinical significance
摘要
Abstract
Objective To investigate the correlation between the expression of cytochrome P450c17α enzyme CYP17A1 and androgen receptor (AR) and the clinical pathology of glioma.Methods The two-step immunohistochemical method was used to measure the expression of CYP17A1 and AR proteins in 55 glioma tissue samples and 10 normal brain tissue samples.Results There was a significant difference in the expression of CYP17A1 protein between high-grade gliomas and low-grade ones (x2 =12.034,P ＜0.05),while there was no expression of CYP17A1 protein in normal brain tissue samples.The expression of CYP17A1 protein was positively correlated with pathological grade (r =0.705,P ＜ 0.05).There was a significant difference in the expression of AR protein between highgrade gliomas and low-grade ones (x2 =19.509,P ＜ 0.05),while there was no expression of AR protein in normal brain tissue samples.The expression of AR protein was positively correlated with pathological grade (r =0.73,P ＜ 0.05).Conclusions Glioma tissues have significantly higher expression of CYP17A1 and AR proteins than normal brain tissues,and the expression of CYP17A1 and AR proteins in glioma tissues are correlated with pathological grade,which suggests that the androgen axis plays an important role in the development and progression of glioma.关键词
胶质瘤/P450c17a酶/雄激素受体/免疫组化染色法Key words
Glioma/P450c17α enzyme/Androgen receptor/Immunohistochemical staining引用本文复制引用
牛万祥,周晨旭,牛朝诗..CYP17A1和AR在脑胶质瘤中的表达及意义[J].国际神经病学神经外科学杂志,2017,44(1):1-4,4.基金项目
安徽省自然科学基金项目(编号:1408085MKL69),脑功能与脑疾病安徽省重点实验室绩效考核补助项目(编号:1506c085017,1606c08235),安徽省科技攻关项目(编号:1604a0802069) （编号:1408085MKL69）
