国际神经病学神经外科学杂志2017，Vol.44Issue(1)：44-48,5.DOI:10.16636/j.cnki.jinn.2017.01.010
2型糖尿病患者基质金属蛋白酶-12基因多态性与缺血性卒中的相关性研究
Association between matrix metalloproteinase-12 gene polymorphisms and ischemic stroke in patients with type 2 diabetes
林芳 1任阳 1冯琳 1刘伟1
作者信息
- 1. 延安大学附属医院老年病科,陕西省延安市716000
- 折叠
摘要
Abstract
Objective To investigate the association between matrix metalloproteinase-12 (MMP-12) gene polymorphisms and ischemic stroke in patients with type 2 diabetes.Methods A total of 217 patients with type 2 diabetes complicated by ischemic stroke who were treated in our department from January 2013 to December 2015 were enrolled as case group,and according to the TOAST type,they were divided into large artery atherosclerosis (LAA) group (88 patients) and non-LAA group (n-LAA group,129 patients).A total of 100 patients with type 2 diabetes who had no ischemic stroke and underwent physical examination in our hospital during the same period of time were enrolled as control group.Polymerase chain reaction-restriction fragment length polymorphism was used to measure the differences in MMP-12 (-82 A/G) and MMP-12 (-1082 A/G) gene polymorphisms between groups.Results There were no significant differences in the frequencies of MMP-12 (82 A/G) genotypes and alleles between the case group and the control group,as well as between the n-LAA group and the control group (P ＞ 0.05).Compared with the control group,the LAA group had significantly higher frequencies of (G/G + A/G) genotypes (22.73％ vs 11.00％,P =0.031) and G allele (18.18％ vs 10.05％,P =0.033).There were no significant differences in the frequencies of MMP-12 (-1082 A/G) genotypes and alleles between the n-LAA group and the control group (P ＞ 0.05).Compared with the control group,the case group and the LAA group had significantly higher frequencies of (G/G + A/G) genotypes (33.64％/37.50％ vs 22.00％,P =0.036 and P =0.020) and G allele (25.58％/ 30.68％ vs 17.00％,P =0.017 and P =0.002).The multivariate logistic regression analysis showed that G allele at MMP-12-82A/G (OR =1.107,95％ CI 1.010-1.371,P =0.031) and G allele at MMP-12-1082A/G (OR =1.285,95％ CI 1.142-1.817,P =0.010) were risk factors for the development of LAA in patients with type 2 diabetes.Condusions For patients with type 2 diabetes,gene polymorphisms of G allele in MMP-12 (-82 A/G) and MMP-12 (-1082 A/G) may be closely associated with LAA.关键词
2型糖尿病/缺血性卒中/基质金属蛋白酶-12/基因多态性Key words
type 2 diabetes/ischemic stroke/matrix metalloproteinase-12/gene polymorphism引用本文复制引用
林芳,任阳,冯琳,刘伟..2型糖尿病患者基质金属蛋白酶-12基因多态性与缺血性卒中的相关性研究[J].国际神经病学神经外科学杂志,2017,44(1):44-48,5.
