广西医科大学学报2017，Vol.34Issue(3)：347-350,4.DOI:10.16190/j.cnki.45-1211/r.2017.03.006
二氢杨梅素对小鼠急性脑缺血缺氧的保护作用
Protective effect of dihydromyricetin on acute cerebral hypoxia-ischemia in mice
摘要
Abstract
Objective:To study the protective effect of dihydromyricetin (DMY) on acute cerebral hypoxiaischemia in mice.Methods:Male Kuming mice were randomly divided into control or sham group,high-and low-dose DMY group,ginaton group and model group.The mice in the high-and low-dose DMY group were administered 500 mg/kg and 250 mg/kg DMY respectively via intragastric gavage for 10 days.At 1 h after the last administration,the gasping time and gasping number of beheaded mice,survival time,oxygen consumption ratio in hypoxia tolerance mice,and survival time in bilateral carotid artery ligation (BCAO) mice were observed.Results:High-and low-dose DMY could significantly increased the gasping time and gasping number of beheaded mice,prolonged the oxygen consumption ratio of hypoxia tolerance mice and the survival time of BCAO mice.High-dos of DMY could also prolong the surviving time of hypoxia tolerance mice.Conclusion:DMY exerted a protective effect on acute cerebral hypoxia-ischemia in mice.关键词
二氢杨梅素/急性脑缺血缺氧/小鼠Key words
dihydromyricetin/acute cerebral ischemia and hypoxia/mice分类
医药卫生引用本文复制引用
韦坤璇,邓之婧,甘露,庞逸敏,何萍,郭哲..二氢杨梅素对小鼠急性脑缺血缺氧的保护作用[J].广西医科大学学报,2017,34(3):347-350,4.基金项目
国家自然科学基金资助项目(No.81360056) （No.81360056）
广西自然科学基金资助项目(No.2012GXNSFCA053005 （）
No.2013GXNSFAA019147) （）
南宁市科学研究与技术开发计划项目(No.20153105) （No.20153105）
