广西医科大学学报2017，Vol.34Issue(3)：367-371,5.DOI:10.16190/j.cnki.45-1211/r.2017.03.011
HIV/AIDS并发口腔念珠菌病54例临床分析
A clinical analysis on 54 HIV/AIDS patients complicated with oral candidiasis
摘要
Abstract
Objective:To analyze the pathogen identification,clinical phenotype and the CD4+ cells in 54 HIV/AIDS patients complicated with oral candidiasis (OC).Methods:54 HIV/AIDS patients with OC treated in our hospital from July 2015 to April 2016 were enrolled and classified according to OC clinical phenotype.Mucosal swab samples were collected,and inoculated to CHROMagar Candida for pathogenic identification.The detection rate of non-albicans Candida species in patients with CD4+ cell count ＜50/mm3 and ＞ 50/mm3 were compared.Results:The OC clinical phenotype mainly manifested in pseudomembranous and erythema types.The detection rate of Candida albicans was the highest (75％),and followed by Candida tropicalis (11.67％).The CD4+ cell count ranged from 5-464 cells/mm3 in 54 cases of OC patients.The detection rate of non-albicans Candida species in patients with CD4+ cell count ＜50/mm3 was higher than those ＞ 50/mm3 (x2 =3.97,P =0.04).Conclusion:The OC clinical phenotypes were mainly pseudomembranous and erythema types,and the main types of pathogen were C.albicans and C.tropicalis in HIV/AIDS patients with OC.Non-albicans Candida was common pathogens in patients with CD4+ cell count ＜50/mm3.关键词
HIV/AIDS/口腔念珠菌病/机会性感染Key words
HIV/AIDS/oral candidiasis/opportunistic infections分类
医药卫生引用本文复制引用
全昌园,黄俏,黄力毅,李庆妮,周丽君,覃金梅,赵玥,黄丽婵,甄秀梅..HIV/AIDS并发口腔念珠菌病54例临床分析[J].广西医科大学学报,2017,34(3):367-371,5.基金项目
国家自然科学基金资助项目(No.81260239 （）
No.81472002) （）
广西壮族自治区科技攻关基金资助项目(No.桂科攻1355005-1-2) （No.桂科攻1355005-1-2）
