摘要
Abstract
Objective:To investigate the clinical efficacy of metoprolol combined with ulinastation on the patients with chronic obstructive pulmonary disease (COPD) complicated with chronic heart failure (CHF).Methods:80 patients with COPD complicated with CHF in our hospital from January 2014 to December 2015 were selected and divided into a control group (n =40) and an observation group (n =40).The patients in the control group received routine treatment with the addition of metoprolola,while those in the observation group were treated as the control group with the addition of ulinastatin.The clinical efficacy,lung function,life quality and adverse reactions were compared between the two groups.Results:The total response rate in the observation group (87.5％) was higher than that in the control group (75.0％) (P ＞0.05).Before treatment,there were no significant differences in the forced expiratory volume in 1 sec.(FEV1),the ratio of FEV1 and forced vital capacity (FVC),the ratio of FEV1 and predictive value between the two groups (P ＞0.05).After 4-month treatment,the FEV1 was (1.51±0.42) L,the FEV1/FVC ratio was (66.08 ±10.11) ％ and the FEV1/pred ratio was (51.38 ± 5.67)％ in the observation group,and were respectively (1.33±0.42)L,(57.88±7.08)％ and (46.33±5.15)％ in the control group.The three lung-function indicators (FEV1,FEV1/FVC and FEV1/pred) in the two groups were statistically different (P ＜0.05).After 7-month treatment,the St George's respiratory questionnaire scores in the observation group was lower than those in the control group (P ＞0.05).No severe complications and adverse reactions occurred in both groups.Conclusion:Metoprolol combined with ulinastation achieved a better effect for treating COPD complicated with CHF,which could improve patients' life quality and did not obviously influence their lung function.关键词
慢性阻塞性肺疾病/慢性心力衰竭/美托洛尔/乌司他丁/临床疗效Key words
chronic obstructive pulmonary disease/chronic heart failure/metoprolol/ulinastation/clinical efficacy分类
医药卫生
