广西植物2017，Vol.37Issue(2)：186-190,5.DOI:10.11931/guihaia.gxzw201609031
植物TIR-NB-LRR类型抗病基因各结构域的研究进展
Research progress on domains of plant TIR-NB-LRR resistance genes
摘要
Abstract
Plant disease-resistance response is a complex process which is regulated by multiple genes. Plant resistance genes ( R genes) play an important role in this process. R genes can be divided into different types based on their N-ter-minal and transmembrane domains. The majority of disease resistance genes in plants encode nucleotide-binding site leu-cine-rich repeat ( NBS-LRR) proteins. The TIR-NB-LRR( TNL) type is a large family of plant NB-LRR genes. And it is also the current hot topics in the studies of plant disease resistance genes. We summarized the related research progresses of different domains of TNL proteins comprehensively in this review. TIR domain in resistance signaling via homodimer-ization or heterodimerization is a major role of plant TNL proteins. However, emerging roles for pathogen recognition for the plant TIR domain were identified in some researches. The NBS domain in NBS-LRR proteins was proposed to func- tion as a molecular switch. It can adjust the conformation changes of plant R proteins through binding ADP or ATP, which regulates resistance signal conduction downstream. The LRRs of plant TIR-NB-LRR proteins were predicted to in-teract directly or indirectly with their avirulent effectors to recognize the pathogen specifically. The information provides a good theory basis for study of plant disease-resistance mechanisms, and also provides new insights and choices for crop disease-resistance breeding directionally by gene editing technology in the future.关键词
抗病基因/TIR结构域/NBS结构域/LRR结构域Key words
resistance genes/TIR domain/NBS domain/LRR domain分类
农业科技引用本文复制引用
尹玲,方辉,黄羽,卢江,曲俊杰..植物TIR-NB-LRR类型抗病基因各结构域的研究进展[J].广西植物,2017,37(2):186-190,5.基金项目
国家自然科学基金(31660567) （31660567）
广西自然科学基金(2016GXNSFBA380029) （2016GXNSFBA380029）
广西农业科学院科技发展基金(桂农科2016JM14,桂农科2015JM28) （桂农科2016JM14,桂农科2015JM28）
广西八桂学者专项( [2013]3号)[Supported by the National Natural Science Foundation of China(31660567) （ [2013]3号）
Natural Science Founda-tion of Guangxi ( 2016GXNSFBA380029 ) （ 2016GXNSFBA380029 ）
Science and Technology Development Fund of Guangxi Academy of Agricultural Sciences ( 2016JM14, 2015JM28) （ 2016JM14, 2015JM28）
Special Fund Program of Bagui Scholars in Guangxi( [2013]3)]. （ [2013]3）
